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Topical›Biology 9700›The mitotic cell cycle›Replication and division of nuclei and cells›Paper 1

Replication and division of nuclei and cells — Paper 1 · A Level Biology 9700

5.1· 187 questions · 187 marks · 224 min · 2004–2025· Multiple choice

Every Cambridge A Level Biology Paper 1 question on replication and division of nuclei and cells, laid out as 49 A4 pages with the mark scheme below. Nothing is left out. Free to read, no account.

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Question 1: The graph shows measurements taken during one mitotic cell cycle. X 2 distance 1 0 5 10 15 20 25 time / minutes Which stage of mitosis begi…Question 2: Human cells contain 46 chromosomes. The diagram shows a human cell in prophase of mitosis (cell 1) and the daughter cells just after teloph…1 / 49
Question 3: Which process occurs during prophase of mitosis in an animal cell? A division of centromeres B formation of chromosomes C replication of DN…Question 4: Which is a feature of all prokaryotic cells? A absence of cell surface membrane B division by mitosis C presence of mitochondria D presence…Question 5: Which cell activity must occur before prophase of mitosis can begin? A breakdown of the nuclear envelope B increased production of mRNA C m…Question 6: What are the conditions in a human cell just before the cell enters prophase? number of number of molecules nuclear envelope spindle presen…Question 7: The diagram shows the mitotic cell cycle. When radioactive nucleotides are supplied to dividing cells, at which point will they be incorpor…2 / 49
Question 8: To which of the processes shown does mitosis make a contribution? enetic variation increase in replacement of g cell number damaged cells…Question 9: A diploid nucleus in a species of fruit fly has 8 chromosomes. How many DNA molecules are present in the nucleus at the end of interphase? …Question 10: Mammalian skin cells in tissue culture were supplied with a source of radioactive thymine. At which stage in the cell cycle will the thymin…Question 11: Which of the following is true of cancer? A Each mitotic division produces more than two daughter cells. B Mitosis has stopped. C Mitosis i…Question 12: Which are features of nuclear division by mitosis? 1 forms cells of equal size to the parent cell 2 forms genetically identical cells 3 sem…3 / 49
Question 13: The diagram shows a process involving DNA. What is the name of the process and the stage in the cell cycle at which it occurs? process stag…Question 14: Which statement describes events during interphase of the mitotic cell cycle? A Chromatids are pulled apart by spindle fibres. B Chromosome…Question 15: Chromosome telomeres promote DNA replication and are not completely replaced during mitosis. A substance X is known that completely replace…4 / 49
Question 16: What is a correct description of the centrioles, nuclear envelope and spindle during mitosis in animal cells? phase centrioles nuclear enve…Question 17: Cancer cells divide out of control, forming tumours. Which statement describes the difference between a cancer cell and a normal cell? A Ca…Question 18: Which statement describes a cell that is capable of reproduction and belonging to a haploid organism? A It has chromosomes that contain one…Question 19: During which stage of the mitotic cell cycle is DNA replicated? A anaphase B interphase C prophase D telophaseQuestion 20: What describes the behaviour of the nuclear envelope and the cell membrane during mitosis? nuclear envelope cell membrane A breaks down bre…5 / 49
Question 21: The cell cycle includes mitosis. Which are features of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically…Question 22: In which process does mitosis not have an important role in living things? A asexual reproduction B growth of cells C increase in size D re…Question 23: Which is always true of cytokinesis? 1 Cell organelles replicate. 2 Cell organelles are divided between two cells. 3 Nuclear envelope refor…6 / 49
Question 24: The diagram shows how genetically identical frogs can be developed from unfertilised frog eggs. The diploid number (2n) for frogs is 26. un…Question 25: The graph represents the changes in the quantity of DNA present in one nucleus at different stages in the life cycle of a mammal. X fertili…7 / 49
Question 26: During which process does only mitosis occur? A the production of antibodies from B-lymphocyte memory cells B the production of cancerous t…Question 27: Which is always true of cytokinesis? 1 Cell organelles replicate. 2 Cell organelles are divided between two cells. 3 Nuclear envelope refor…Question 28: The diagram shows how genetically identical frogs can be developed from unfertilised frog eggs. The diploid number (2n) for frogs is 26. un…8 / 49
Question 29: In general, eukaryotic cells undergo division much slower than prokaryotic cells. What is the reason for this? A Eukaryotes break down the …Question 30: Which statement about a diploid cell is not correct? A It can undergo a mitotic division to allow growth to occur. B It can undergo a mitot…Question 31: Meiosis and mitosis are two types of cell division. A cell has 10 chromosomes before it divides. How many chromosomes will it have after di…Question 32: A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase and prevents its replication. A carcinogen i…Question 33: In general, eukaryotic cells undergo division much slower than prokaryotic cells. What is the reason for this? A Eukaryotes break down the …9 / 49
Question 34: Which statement about a diploid cell is not correct? A It can undergo a mitotic division to allow growth to occur. B It can undergo a mitot…Question 35: Meiosis and mitosis are two types of cell division. A cell has 10 chromosomes before it divides. How many chromosomes will it have after di…Question 36: A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase and prevents its replication. A carcinogen i…Question 37: For organisms undergoing sexual reproduction, a reduction division occurs before fertilisation. Which reasons explain why this is necessary…10 / 49
Question 38: What are the conditions in a human cell just before the cell enters prophase? number of number of molecules nuclear envelope spindle presen…Question 39: The diagram shows the cell cycle. When radioactive nucleotides are supplied to dividing cells, at which point will they be incorporated int…Question 40: For organisms undergoing sexual reproduction, a reduction division occurs before fertilisation. Which reasons explain why this is necessary…Question 41: What are the conditions in a human cell just before the cell enters prophase? number of number of molecules nuclear envelope spindle presen…11 / 49
Question 42: Which statement is incorrect for mitotic cell division? A DNA is replicated semi-conservatively during mitosis. B DNA is normally unchanged…Question 43: Immediately after which stage in mitosis in an animal cell does the cytoplasm start to divide? A anaphase B metaphase C prophase D telophaseQuestion 44: Colchicine is a substance which inhibits the formation of spindle fibres. At which stage is the cell cycle interrupted? A cell division B D…Question 45: Which statement describes a cell belonging to a haploid organism that is capable of reproduction? A It has chromosomes that contain one pol…Question 46: Some chemicals, used to stop tumour growth, work by preventing the DNA double helix from uncoiling and separating. During which stage of th…12 / 49
Question 47: Chromosome telomeres are essential for DNA replication and are not completely replaced during mitosis. A substance X is known that complete…Question 48: The diagram shows a cell nucleus in prophase of mitosis. Which statement describes the chromosomes found in each daughter nucleus immediate…Question 49: Which features of mitosis ensure that the genetic constitution of the cell is maintained? 1 the position of the chromosomes on the equator …13 / 49
Question 50: Uncontrolled cell division of cancer cells forms tumours. Which statement describes the difference between a cancer cell and a normal cell?…Question 51: Exposure to which of the following increases the risk of developing a cancerous growth? ultraviolet viruses carbon X-rays light monoxide y…Question 52: The diagram shows an outline of the process of sexual reproduction. adult cell adult cell 1 1 gamete P gamete fertilisation Q zygote 2 fetu…14 / 49
Question 53: What correctly describes the effect of carcinogens on lung tissue? A Cells of the alveoli walls divide more rapidly than normal by reductio…Question 54: Which statements about cancer are correct? 1 Exposure to UV light from the sun always causes skin cancer. 2 Some viruses can cause cancer. …Question 55: The diagram represents the life cycle of a sexually reproducing animal. n n 3 4 1 2 2n 2n 2n n n Which row correctly identifies meiosis and…Question 56: The diagram shows part of the life cycle of the honey bee, Apis mellifera. 2 unfertilised male drones 1 (n = 16) queen gametes (2n = 32) (n…15 / 49
Question 57: Which processes occur by mitosis? 1 cloning of plasma cells 2 gamete production 3 replacing damaged cells A 1, 2 and 3 B 1 and 3 only C 2 o…Question 58: The diagram shows crosses between wild wheat and two types of grass. wild wheat × goat grass 2n = 14 2n = 14 sterile hybrid mutation double…Question 59: The cell cycle includes mitosis. Which are features of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically…Question 60: Which is the correct statement concerning cell and nuclear division? A Haploid eukaryotes can reproduce by mitosis whereas diploid eukaryot…16 / 49
Question 61: During which process does only mitosis occur? A the production of antibodies from B-lymphocyte memory cells B the production of cancerous t…Question 62: Which statement about a diploid cell is not correct? A It can undergo a mitotic division to allow growth to occur. B It can undergo a mitot…Question 63: Laboratory mice whose p53 genes had been switched off developed tumours. When their p53 genes were switched on again, the tumour cells stop…Question 64: A student examined the cells in the growing region (meristem) of an onion root and obtained the data below. stage number of cells interphas…Question 65: Which definitions of diploid and haploid are true for typical eukaryotic cells? 1 diploid – any cell with an even number of homologous chro…17 / 49
Question 66: Which is always true of cytokinesis? 1 Cell structures replicate. 2 Cell structures are divided between two cells. 3 Nuclear envelope refor…Question 67: The graphs show various measurements taken from metaphase of mitosis onwards. The graphs are to scale when compared to one another. X dista…18 / 49
Question 68: A scientist counted 22 chromosomes in each of the root cells of a xerophytic plant. What is the diploid and haploid number of chromosomes f…Question 69: Which diagrams show the correct relationships? conservation increase in DNA A of chromosome mitosis 2n n chromosome 2n 4n rep…19 / 49
Question 70: The diagram represents stages in the life cycle of an organism. cells of P cells of gamete gamete parent 1 parent 2 Q zygote R adult Which …Question 71: Which statements about a diploid cell are correct? 1 can divide by mitosis to repair itself 2 has two complete sets of chromosomes 3 can un…Question 72: Which metabolic processes will be very active in a cell that has just completed cytokinesis? 1 ATP formation 2 DNA replication 3 protein sy…Question 73: Which row shows the products of mitosis, reduction division (meiosis) and fertilisation? products products of product of of mitosis meiosis…20 / 49
Question 74: Which statements about the cell cycle are correct? 1 The cell cycle consists of both interphase and mitosis. 2 DNA replication takes place …Question 75: The protein p53 is produced in a cell in response to DNA damage. This protein stops the cell cycle for a short time just before the DNA is …Question 76: Which feature of stem cells enables them to replace cells in tissues such as the skin? A They are undifferentiated cells that are present a…Question 77: Mitosis is an important process for organisms. Which features of mitosis are important for single-celled organisms? 1 asexual reproduction …Question 78: Which processes occur in bone marrow cells that are in a mitotic cell cycle? 1 phosphate groups bind to ADP molecules to form ATP 2 bonds f…Question 79: Which event is part of the mitotic cell cycle? A anaphase B cytokinesis C DNA replication D interphase21 / 49
Question 80: Chromosome telomeres are essential for DNA replication and are not completely replaced during mitosis. Substance X completely replaces telo…Question 81: Some stem cells divide and give rise to phagocytes. Where in the human body do these stem cells divide? 1 blood 2 bone marrow 3 lymph nodes…Question 82: What is the correct sequence of stages in the mitotic cell cycle? A G1 → G2 → mitosis → S → cytokinesis B G1 → G2 → S → mitosis → cytokines…Question 83: The enzyme telomerase repairs telomeres. It stops the telomeres from getting shorter each time a chromosome is replicated. Telomerase is no…22 / 49
Question 84: Bacterial cells divide by a process called binary fission. Which macromolecules must be synthesised for binary fission? 1 cell membrane pro…Question 85: The diagram shows the mitotic cell cycle. During which phase is DNA replicated? cell division D C B AQuestion 86: The diagram shows the cell cycle of a mammalian cell. G2 M S cytokinesis G1 Checkpoints in the cell cycle of mammals prevent the cycle from…23 / 49
Question 87: The photomicrographs show cells in various stages of the cell cycle. In which stage does semi-conservative replication of DNA take place? A…Question 88: Cancer cells may divide by far more divisions than other cells found in humans. Which statement about cancer cells is correct? A They are a…Question 89: Uncontrolled cell division can form tumours. Which statement is correct for tumour cells only? A Metaphase does not take place. B Cytokines…Question 90: Which of these events are part of mitosis? 1 interphase 2 anaphase 3 cytokinesis A 1, 2 and 3 B 1 and 3 only C 1 only D 2 onlyQuestion 91: Which of these processes will require ATP? 1 transport of water in the xylem 2 semi-conservative replication of DNA 3 facilitated diffusion…24 / 49
Question 92: How many copies of each different DNA molecule will be found in a cell at the start of each of these stages of the mitotic cell cycle? G2 o…Question 93: A student observed the cells in the growing region (meristem) of an onion root and obtained the data shown. stage number of cells interphas…Question 94: Which of these events are part of mitosis? 1 interphase 2 telophase 3 cytokinesis A 1, 2 and 3 B 1 and 3 only C 1 only D 2 onlyQuestion 95: During which phase of the cell cycle does DNA replication take place? A G1 B G2 C M D SQuestion 96: One of the chromosomes in a nucleus has a telomere which contains many repeats of the base sequence TTAGGG. This chromosome was extracted f…25 / 49
Question 97: Which of these statements about cytokinesis is always true? 1 Cell structures replicate. 2 Cell structures are shared between two cells. 3 …Question 98: Which features of an organism are affected by a drug that stops mitosis? 1 cell repair 2 cell replacement 3 number of stem cells 4 tissue r…Question 99: How many copies of each DNA molecule will be found in a cell at each stage of the mitotic cell cycle? G1 of cytokinesis interphase A 1 1 B …Question 100: Which metabolic processes will be very active in a cell that has just completed cytokinesis? 1 ATP formation 2 DNA replication 3 protein sy…Question 101: A mutation occurs in a gene which prevents the production of telomerase. What is the effect of this mutation if it occurs in bone marrow st…26 / 49
Question 102: The photomicrograph shows cells in different stages of mitosis. P T Q S R Which statements are correct? 1 Cell T shows metaphase. 2 DNA rep…Question 103: Which changes in a group of mammalian cells, dividing by mitosis, would be necessary for the formation of a tumour? 1 Mitosis is no longer …Question 104: How many copies of each DNA molecule will be found in a cell at each stage of the mitotic cell cycle? G2 of metaphase cytokinesis interphas…27 / 49
Question 105: Embryonic stem cells are able to replicate continuously. What happens to the telomeres during repeated mitotic cell cycles of embryonic ste…Question 106: Which events listed are part of mitosis? 1 interphase 2 prophase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 only D 2 onlyQuestion 107: The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells need to transcribe telomerase enzyme? 1 cancer…Question 108: The diagram shows some of the stages which take place during the cell cycle. 1 number of DNA molecules in cell doubles 4 stages 2 nuclear e…28 / 49
Question 109: The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells need to transcribe telomerase enzyme? 1 stem c…Question 110: A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase and prevents its replication. A carcinogen i…Question 111: The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells transcribe a high concentration of telomerase?…Question 112: The cell cycle includes mitosis. Which are features of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically…Question 113: The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which types of white blood cell involved in an autoimmune…29 / 49
Question 114: Which processes that occur in cell division are represented in the diagram? 4 3 mass of nuclear DNA in a cell 2 / arbitrary units 1 0 time …Question 115: What happens to the telomeres during mitosis of a cancer cell? A The length increases. B The length decreases. C They are completely lost. …Question 116: The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Three types of cell are used to produce monoclonal antibod…Question 117: Which cells contain telomeres that are longer than those in a helper T-lymphocyte secreting cytokines? 1 bone marrow stem cells 2 mature re…30 / 49
Question 118: In which stage of the cell cycle are telomeres needed to prevent the loss of genes? A prophase B cytokinesis C G1 phase D S phaseQuestion 119: Which feature of stem cells enables them to replace cells in tissues such as the skin? A They are undifferentiated cells that are present a…Question 120: The diagram shows the cell cycle. During which phase do chromosomes condense and become visible? cytokinesis D C A BQuestion 121: Which processes involve mitosis? clonal selection forming cells at the of T-lymphocytes tip of a growing root B A C D replacing skin cells …31 / 49
Question 122: The diagram shows the relative time taken for each stage in the cell cycle. X Y Z Which row identifies the correct sequence of the stages i…Question 123: The electron micrograph shows a cell structure in a eukaryotic cell. Which statements about this cell structure are correct? 1 ATP is synth…Question 124: Methotrexate is a drug used to treat cancer. It can act as an enzyme inhibitor preventing the synthesis of nucleotides containing thymine. …32 / 49
Question 125: Which features of mitosis are important for a single-celled organism? 1 asexual reproduction 2 production of genetically identical cells 3 …Question 126: Some events in the cell cycle are listed. Which events are part of mitosis? 1 interphase 2 metaphase 3 cytokinesis A 1, 2 and 3 B 1 and 3 o…Question 127: Which letter identifies cell structures where semi-conservative replication of DNA occurs? chloroplasts B A mitochondria nuclei D CQuestion 128: Which statements about mitosis are correct? 1 Mitosis results in genetically identical cells. 2 Mitosis is involved in asexual reproduction…33 / 49
Question 129: The jellyfish, Turritopsis dohrnii, is described as being immortal. If T. dohrnii is not eaten by predators or diseased, it seems to be abl…Question 130: Some chemicals, used to stop tumour growth, work by preventing the DNA double helix from uncoiling and separating. During which stage of th…Question 131: The diagram represents the cell cycle of a human cell. During the cell cycle the number of chromatids changes. mitosis G2 M S C cytokinesis…34 / 49
Question 132: A single skin cell was isolated and transferred to growth medium in a sterile Petri dish. The Petri dish was incubated for 16 days. During …Question 133: How many copies of each different DNA molecule are found in a cell at the start of each of these stages of the mitotic cell cycle? G2 of pr…Question 134: Hydra are simple animals which can reproduce asexually. The photomicrograph shows an adult hydra with a new hydra developing while attached…35 / 49
Question 135: What will be present in each chromosome at the end of the G2 phase of the cell cycle? A two centrioles B two centromeres C two molecules of…Question 136: Which events listed are part of the cell cycle? 1 interphase 2 metaphase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3…Question 137: Which features of an organism are affected by a drug that kills cells that are dividing mitotically? 1 cell repair 2 cell replacement 3 num…Question 138: The photomicrographs show cells in various stages of the cell cycle. 1 2 3 4 Which cells contain twice as many DNA molecules as a cell from…36 / 49
Question 139: Uncontrolled cell division can result in the formation of a tumour. Which part of the cell cycle would take less time during the formation …Question 140: Some processes are listed.  cytokinesis  differentiation  DNA replication  mitosis How many of the listed processes occur during tissue…Question 141: The protein p53 is produced in a cell in response to DNA damage. This protein stops the cell cycle for a short time just before the DNA is …Question 142: Which processes require mitosis? 1 the cloning of T-lymphocytes 2 the repair of cell structures by protein synthesis 3 the growth of multic…Question 143: Which events listed are part of the cell cycle? 1 interphase 2 prophase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 …37 / 49
Question 144: Telomerase is an enzyme that adds nucleotides to telomeres. Which statement about telomerase is correct? A A high concentration of telomera…Question 145: What is a role of mitosis? A growth of organisms B production of genetically different cells C repair of cells D replacement of cancerous t…Question 146: Telomeres prevent the loss of genes from the ends of chromosomes during DNA replication, but they become shorter each time they are copied.…Question 147: The nucleus of a mouse body cell in G1 phase of the cell cycle has 1.2  10–12 g of DNA. What will be the mass of DNA in the nucleus of the…38 / 49
Question 148: Some cells are listed. 1 bacterial cells 2 cancer cells 3 lymphocytes 4 mature red blood cells 5 stem cells Which cells can divide by mitos…Question 149: Which statement about telomeres is correct? A They allow cells in culture from any age of donor to divide a fixed number of times. B They a…Question 150: How many of these processes produce genetically identical cells? ● growth of plant roots ● replacement of dead human skin cells ● repair of…Question 151: Which processes occur during interphase? 1 DNA replication 2 microtubule organisation 3 synthesis of ribosomes A 1, 2 and 3 B 1 and 2 only …Question 152: Embryonic stem cells are able to replicate continuously. What happens to the telomeres during repeated mitotic cell cycles of embryonic ste…39 / 49
Question 153: The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells need to transcribe telomerase enzyme? 1 cancer…Question 154: Which processes that occur in the cell cycle are represented in the diagram? 4 3 mass of nuclear DNA in a cell 2 / arbitrary units 1 0 time…Question 155: A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase and prevents its replication. A carcinogen i…Question 156: The photomicrographs show cells in various stages of the cell cycle. In which stage does semi-conservative replication of DNA take place? A…40 / 49
Question 157: The diagram shows the epidermis of human skin. This is formed of four layers of cells. Cells in each layer have specific functions which ar…Question 158: The diagram shows some of the stages that take place during the cell cycle. 1 number of DNA molecules in cell doubles 4 stages 2 nuclear en…Question 159: Which events are part of the mitotic cell cycle? 1 interphase 2 telophase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and …41 / 49
Question 160: The estimated total number of red blood cells in the human body is 2.5  1013. It is estimated that, each day, 2.5  1011 red blood cells a…Question 161: The cell cycle includes mitosis. What are features of this type of nuclear division? 1 forms cells of equal size to the parent cell 2 forms…Question 162: How many copies of each DNA molecule will be found in a cell at the start of the stages of the mitotic cell cycle shown? G1 of cytokinesis …Question 163: Which row describes some properties of stem cells? able to divide by mitosis to produce more stem cells able to differentiate into spec…42 / 49
Question 164: The mitotic index is a measure of the proportion of cells that are undergoing mitosis in an area of tissue. It is calculated using the form…Question 165: A human embryo consists of 12 cells at the start of day 1. The cells divide by mitosis for 4 complete days at a rate of 1 division every 32…43 / 49
Question 166: Which diagrams show roles of mitosis? 1 2 3 4 A 1, 2, 3 and 4 B 1, 2 and 3 only C 1 and 2 only D 3 and 4 onlyQuestion 167: Which events are part of the mitotic cell cycle? 1 interphase 2 anaphase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only44 / 49
Question 168: Which statements correctly describe features of stem cells that are essential for their role in cell replacement and tissue repair? 1 After…Question 169: Why is mitosis important in the immune response? A It allows B-lymphocytes to produce plasma cells. B It allows B-lymphocytes to synthesise…Question 170: Which metabolic processes will be very active in a cell that has just completed cytokinesis? 1 ATP formation 2 DNA replication 3 protein sy…45 / 49
Question 171: The diagram shows a typical mitotic cell cycle and the point in the cell cycle that has been reached by each of four cells, V, W, X and Y. …Question 172: The contents of a daughter cell are compared to the parent cell after one cell cycle. Which row is correct? number of volume of length of c…Question 173: Which statements about the cell cycle are correct? 1 The cell cycle includes interphase and mitosis. 2 DNA replication takes place in inter…46 / 49
Question 174: What are the correct roles of mitosis? stem cell growth replacing lost skin cells 00O WwW > x x LOK \ -« \ x& key ¥ = correct X = no…Question 175: Which row about the stages of the mitotic cell cycle is correct? RNA polymerase DNA ligase used used in the in the nucleus nucleus A G1 pha…Question 176: Which processes occur in bone marrow cells that are in a mitotic cell cycle? 1 Phosphate groups bind to ADP molecules to form ATP. 2 Bonds …Question 177: The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells need to transcribe telomerase enzyme? 1 stem c…Question 178: Which process does not involve mitosis? A asexual reproduction B growth of unicellular organisms C repair of tissues by cell replacement D …47 / 49
Question 179: The diagram shows an outline of the mitotic cell cycle. 1 2 cytokinesis 3 Which numbered stages of the cell cycle include a period of time …Question 180: A nucleus in a body cell of a species of fruit fly has 8 chromosomes. How many strands of DNA are present in the nucleus at the end of inte…Question 181: The statements are about two genes and their protein products that can have a role in tumour formation. ● The protein coded for by the PTEN…Question 182: Telomerase is an enzyme that prevents the shortening of telomeres. It is not present in most normal cells, but is active in an estimated 85…48 / 49
Question 183: During which phase of the cell cycle does DNA replication take place? A G1 B G2 C M D SQuestion 184: The epithelium that lines the stomach is damaged by acid and is renewed every two days. Why is mitosis required to repair the damage? A Mit…Question 185: Telomeres become shorter during each cell cycle of a specialised cell. In which phase of the cell cycle do telomeres shorten? A cytokinesis…Question 186: What are roles of adult stem cells in humans? 1 repair other cells by mitosis 2 divide to replace cells in tissues 3 differentiate into a n…Question 187: Which statements are correct for the mitotic cell cycle? 1 DNA is replicated semi-conservatively during mitosis. 2 DNA is never changed fro…49 / 49

Mark scheme187 answers

Answers below. Sit the paper first if you are practising.

Pastlit

Biology 9700 · Replication and division of nuclei and cells — Paper 1

A Level · topical answer key — answer key (teacher use)

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Answer

Marks

1A1
2D1
3D1
4D1
5D1
6D1
7A1
8A1
9C1
10A1
11C1
12C1
13A1
14B1
15A1
16C1
17B1
18D1
19B1
20B1
21A1
22B1
23C1
24C1
25D1
26B1
27C1
28C1
29A1
30B1
31A1
32B1
33A1
34B1
35A1
36B1
37B1
38D1
39A1
40B1
41D1
42A1
43D1
44D1
45D1
46B1
47A1
48B1
49C1
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Pastlit

Biology 9700 · Replication and division of nuclei and cells — Paper 1

A Level · topical answer key — answer key (teacher use)

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Answer

Marks

50C1
51A1
52B1
53C1
54D1
55C1
56D1
57B1
58B1
59D1
60A1
61B1
62B1
63C1
64C1
65D1
66C1
67C1
68B1
69D1
70D1
71D1
72B1
73C1
74A1
75B1
76C1
77B1
78—1
79A1
80A1
81C1
82C1
83A1
84B1
85B1
86B1
87C1
88A1
89C1
90D1
91D1
92D1
93B1
94D1
95D1
96A1
97C1
98D1
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Pastlit

Biology 9700 · Replication and division of nuclei and cells — Paper 1

A Level · topical answer key — answer key (teacher use)

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Answer

Marks

99B1
100B1
101C1
102C1
103B1
104D1
105D1
106D1
107A1
108A1
109B1
110B1
111D1
112D1
113C1
114B1
115D1
116C1
117B1
118D1
119C1
120D1
121C1
122C1
123C1
124B1
125B1
126D1
127A1
128C1
129C1
130B1
131C1
132A1
133D1
134A1
135C1
136A1
137D1
138A1
139B1
140D1
141B1
142B1
143A1
144D1
145A1
146A1
147D1
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Pastlit

Biology 9700 · Replication and division of nuclei and cells — Paper 1

A Level · topical answer key — answer key (teacher use)

Question

Answer

Marks

148C1
149D1
150D1
151C1
152D1
153A1
154B1
155B1
156C1
157B1
158A1
159A1
160C1
161D1
162B1
163B1
164C1
165B1
166A1
167A1
168C1
169A1
170B1
171D1
172D1
173A1
174D1
175D1
176A1
177B1
178B1
179A1
180C1
181A1
182C1
183D1
184C1
185C1
186D1
187D1
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Questions as text

Q1 · The graph shows measurements taken during one mitotic cell cycle 9700/11 Oct/Nov 2004

19 The graph shows measurements taken during one mitotic cell cycle. X 2 distance 1 0 5 10 15 20 25 time / minutes Which stage of mitosis begins at X and which measurements are shown by curves 1 and 2? distance between distance between stage centromeres of centromeres of beginning at X chromosomes and sister chromatids poles of spindle A anaphase 1 2 B anaphase 2 1 C metaphase 1 2 D metaphase 2 1

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2004

Q2 · Human cells contain 46 chromosomes 9700/11 Oct/Nov 2004

20 Human cells contain 46 chromosomes. The diagram shows a human cell in prophase of mitosis (cell 1) and the daughter cells just after telophase (cells 2 and 3). cell 1 cell 2 cell 3 How many DNA molecules are there in the nucleus of cell 1 and cell 2? cell 1 cell 2 A 46 23 B 46 46 C 92 23 D 92 46

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2004

Q3 · Which process occurs during prophase of mitosis in an animal cell? 9700/11 Oct/Nov 2004

21 Which process occurs during prophase of mitosis in an animal cell? A division of centromeres B formation of chromosomes C replication of DNA D separation of centrioles

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2004

Q4 · Which is a feature of all prokaryotic cells? 9700/11 May/June 2006

5 Which is a feature of all prokaryotic cells? A absence of cell surface membrane B division by mitosis C presence of mitochondria D presence of ribosomes

1 marks

Answer: D

This question in 9700/11 May/June 2006

Q5 · Which cell activity must occur before prophase of mitosis can begin? 9700/11 May/June 2006

18 Which cell activity must occur before prophase of mitosis can begin? A breakdown of the nuclear envelope B increased production of mRNA C migration of centrioles to opposite poles D replication of DNA

1 marks

Answer: D

This question in 9700/11 May/June 2006

Q6 · What are the conditions in a human cell just before the cell enters prophase? 9700/11 May/June 2006

19 What are the conditions in a human cell just before the cell enters prophase? number of number of molecules nuclear envelope spindle present chromatids of DNA in nucleus present A 46 46 yes no B 92 46 no yes C 46 92 yes yes D 92 92 no yes

1 marks

Answer: D

This question in 9700/11 May/June 2006

Q7 · The diagram shows the mitotic cell cycle 9700/11 May/June 2006

20 The diagram shows the mitotic cell cycle. When radioactive nucleotides are supplied to dividing cells, at which point will they be incorporated into the chromosomes? mitosis B C D A interphase

1 marks

Answer: A

This question in 9700/11 May/June 2006

Q8 · To which of the processes shown does mitosis make a contribution? 9700/11 Oct/Nov 2006

17 To which of the processes shown does mitosis make a contribution? enetic variation increase in replacement of g cell number damaged cells A x v Jv B Jv x x Cc v v x D x x v key Y contributes to process X does not contribute to process

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2006

Q9 · A diploid nucleus in a species of fruit fly has 8 chromosomes 9700/11 Oct/Nov 2006

19 A diploid nucleus in a species of fruit fly has 8 chromosomes. How many DNA molecules are present in the nucleus at the end of interphase? A 4 B 8 C 16 D 32

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2006

Q10 · Mammalian skin cells in tissue culture were supplied with a source of radioactive thymine 9700/11 Oct/Nov 2006

23 Mammalian skin cells in tissue culture were supplied with a source of radioactive thymine. At which stage in the cell cycle will the thymine be used in the nuclei? A interphase B metaphase C prophase D telophase

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2006

Q11 · Which of the following is true of cancer? 9700/11 Oct/Nov 2007

18 Which of the following is true of cancer? A Each mitotic division produces more than two daughter cells. B Mitosis has stopped. C Mitosis is uncontrolled. D Mitosis results in cells with variable numbers of chromosomes.

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2007

Q12 · Which are features of nuclear division by mitosis? 9700/11 May/June 2008

18 Which are features of nuclear division by mitosis? 1 forms cells of equal size to the parent cell 2 forms genetically identical cells 3 semi-conservative replication of DNA A 1 and 2 only B 2 and 3 only C 2 only D 1, 2 and 3

1 marks

Answer: C

This question in 9700/11 May/June 2008

Q13 · The diagram shows a process involving DNA 9700/11 May/June 2008

22 The diagram shows a process involving DNA. What is the name of the process and the stage in the cell cycle at which it occurs? process stage A replication interphase B replication prophase C transcription interphase D transcription prophase

1 marks

Answer: A

This question in 9700/11 May/June 2008

Q14 · Which statement describes events during interphase of the mitotic cell cycle? 9700/11 Oct/Nov 2008

17 Which statement describes events during interphase of the mitotic cell cycle? A Chromatids are pulled apart by spindle fibres. B Chromosomes are replicated ready for the next division. C Chromosomes line up on the equator of the spindle. D Chromosomes start to coil, becoming shorter and fatter.

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2008

Q15 · Chromosome telomeres promote DNA replication and are not completely replaced during… 9700/11 Oct/Nov 2008

18 Chromosome telomeres promote DNA replication and are not completely replaced during mitosis. A substance X is known that completely replaces telomeres during mitosis. What will be the effect of growing a cell culture with and without substance X? with substance X without substance X A cells divide continually cell division eventually slows and stops B cells divide more rapidly cells divide continually C cell division eventually slows cell division stops immediately and stops D cell division stops immediately cells divide continually

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2008

Q16 · What is a correct description of the centrioles, nuclear envelope and spindle during… 9700/11 Oct/Nov 2008

19 What is a correct description of the centrioles, nuclear envelope and spindle during mitosis in animal cells? phase centrioles nuclear envelope spindle A anaphase replicate absent present B metaphase present reforms present C prophase move apart breaks up forms D telophase replicate breaks up breaks up

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2008

Q17 · Cancer cells divide out of control, forming tumours 9700/12 Oct/Nov 2009

18 Cancer cells divide out of control, forming tumours. Which statement describes the difference between a cancer cell and a normal cell? A Cancer cells do not undergo cytokinesis. B Cancer cells have a shorter interphase. C Cancer cells do not have metaphase. D Only cancer cells have mutated DNA.

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2009

Q18 · Which statement describes a cell that is capable of reproduction and belonging to a… 9700/12 Oct/Nov 2009

19 Which statement describes a cell that is capable of reproduction and belonging to a haploid organism? A It has chromosomes that contain one polynucleotide chain. B It is capable of carrying out a reduction division to form gametes. C It possesses two copies of each gene as a result of fertilisation. D It will undergo cell division by mitosis during asexual reproduction.

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2009

Q19 · During which stage of the mitotic cell cycle is DNA replicated? 9700/12 Oct/Nov 2009

20 During which stage of the mitotic cell cycle is DNA replicated? A anaphase B interphase C prophase D telophase

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2009

Q20 · What describes the behaviour of the nuclear envelope and the cell membrane during mitosis? 9700/11 Oct/Nov 2010

19 What describes the behaviour of the nuclear envelope and the cell membrane during mitosis? nuclear envelope cell membrane A breaks down breaks down B breaks down remains intact C remains intact breaks down D remains intact remains intact

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2010

Q21 · The cell cycle includes mitosis 9700/12 Oct/Nov 2010

16 The cell cycle includes mitosis. Which are features of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically identical cells 3 semi-conservative replication of DNA A 2 only B 1 and 2 only C 2 and 3 only D 1, 2 and 3

1 marks

Answer: A

This question in 9700/12 Oct/Nov 2010

Q22 · In which process does mitosis not have an important role in living things? 9700/12 Oct/Nov 2010

17 In which process does mitosis not have an important role in living things? A asexual reproduction B growth of cells C increase in size D repair to damaged tissues

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2010

Q23 · Which is always true of cytokinesis? 9700/11 May/June 2011

18 Which is always true of cytokinesis? 1 Cell organelles replicate. 2 Cell organelles are divided between two cells. 3 Nuclear envelope reforms. A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: C

This question in 9700/11 May/June 2011

Q24 · The diagram shows how genetically identical frogs can be developed from unfertilised frog… 9700/11 May/June 2011

20 The diagram shows how genetically identical frogs can be developed from unfertilised frog eggs. The diploid number (2n) for frogs is 26. unfertilised V frog egg cell taken from frog nucleus destroyed by W ultra violet radiation nucleus taken X from cell and injected into egg egg develops into tadpole tadpole develops into frog Which combination of numbers correctly identifies the number of chromosomes in each of the types of cell in the diagram? V W X A 13 13 26 B 13 26 13 C 13 26 26 D 26 26 13

1 marks

Answer: C

This question in 9700/11 May/June 2011

Q25 · The graph represents the changes in the quantity of DNA present in one nucleus at… 9700/12 May/June 2011

18 The graph represents the changes in the quantity of DNA present in one nucleus at different stages in the life cycle of a mammal. X fertilisation 4 DNA content 3 / arbitrary units 2 egg 1 time Which stage takes place at X? A interphase B metaphase C prophase D telophase

1 marks

Answer: D

This question in 9700/12 May/June 2011

Q26 · During which process does only mitosis occur? 9700/12 May/June 2011

20 During which process does only mitosis occur? A the production of antibodies from B-lymphocyte memory cells B the production of cancerous tissue in alveoli C the production of gametes D the production of root hairs

1 marks

Answer: B

This question in 9700/12 May/June 2011

Q27 · Which is always true of cytokinesis? 9700/13 May/June 2011

27 Which is always true of cytokinesis? 1 Cell organelles replicate. 2 Cell organelles are divided between two cells. 3 Nuclear envelope reforms. A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: C

This question in 9700/13 May/June 2011

Q28 · The diagram shows how genetically identical frogs can be developed from unfertilised frog… 9700/13 May/June 2011

28 The diagram shows how genetically identical frogs can be developed from unfertilised frog eggs. The diploid number (2n) for frogs is 26. unfertilised V frog egg cell taken from frog nucleus destroyed by W ultra violet radiation nucleus taken X from cell and injected into egg egg develops into tadpole tadpole develops into frog Which combination of numbers correctly identifies the number of chromosomes in each of the types of cell in the diagram? V W X A 13 13 26 B 13 26 13 C 13 26 26 D 26 26 13

1 marks

Answer: C

This question in 9700/13 May/June 2011

Q29 · In general, eukaryotic cells undergo division much slower than prokaryotic cells 9700/11 Oct/Nov 2011

6 In general, eukaryotic cells undergo division much slower than prokaryotic cells. What is the reason for this? A Eukaryotes break down the nuclear membrane during mitosis. B Eukaryotes have many more mitochondria than prokaryotes. C Prokaryotes do not contain any centrioles. D Prokaryotic cells are a lot smaller than eukaryotic cells.

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2011

Q30 · Which statement about a diploid cell is not correct? 9700/11 Oct/Nov 2011

17 Which statement about a diploid cell is not correct? A It can undergo a mitotic division to allow growth to occur. B It can undergo a mitotic division to repair a cell. C It can undergo a reduction division to form haploid cells. D It is one that possesses two complete sets of chromosomes.

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2011

Q31 · Meiosis and mitosis are two types of cell division 9700/11 Oct/Nov 2011

18 Meiosis and mitosis are two types of cell division. A cell has 10 chromosomes before it divides. How many chromosomes will it have after dividing by meiosis or mitosis? meiosis mitosis A 5 10 B 5 20 C 10 5 D 20 5

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2011

Q32 · A gene codes for the production of a protein, p53, that binds to damaged DNA during… 9700/11 Oct/Nov 2011

19 A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase and prevents its replication. A carcinogen in cigarette smoke mutates this gene. Which statement explains why this mutation may cause cancer? A Lack of p53 allows cells to undergo mitosis. B Lack of p53 allows cells with damaged DNA to replicate. C The carcinogen in cigarette smoke increases the rate of cell division. D The p53 causes uncontrolled cell division.

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2011

Q33 · In general, eukaryotic cells undergo division much slower than prokaryotic cells 9700/13 Oct/Nov 2011

4 In general, eukaryotic cells undergo division much slower than prokaryotic cells. What is the reason for this? A Eukaryotes break down the nuclear membrane during mitosis. B Eukaryotes have many more mitochondria than prokaryotes. C Prokaryotes do not contain any centrioles. D Prokaryotic cells are a lot smaller than eukaryotic cells.

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2011

Q34 · Which statement about a diploid cell is not correct? 9700/13 Oct/Nov 2011

27 Which statement about a diploid cell is not correct? A It can undergo a mitotic division to allow growth to occur. B It can undergo a mitotic division to repair a cell. C It can undergo a reduction division to form haploid cells. D It is one that possesses two complete sets of chromosomes.

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2011

Q35 · Meiosis and mitosis are two types of cell division 9700/13 Oct/Nov 2011

28 Meiosis and mitosis are two types of cell division. A cell has 10 chromosomes before it divides. How many chromosomes will it have after dividing by meiosis or mitosis? meiosis mitosis A 5 10 B 5 20 C 10 5 D 20 5

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2011

Q36 · A gene codes for the production of a protein, p53, that binds to damaged DNA during… 9700/13 Oct/Nov 2011

31 A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase and prevents its replication. A carcinogen in cigarette smoke mutates this gene. Which statement explains why this mutation may cause cancer? A Lack of p53 allows cells to undergo mitosis. B Lack of p53 allows cells with damaged DNA to replicate. C The carcinogen in cigarette smoke increases the rate of cell division. D The p53 causes uncontrolled cell division.

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2011

Q37 · For organisms undergoing sexual reproduction, a reduction division occurs before… 9700/11 May/June 2012

17 For organisms undergoing sexual reproduction, a reduction division occurs before fertilisation. Which reasons explain why this is necessary? 1 increase genetic variation 2 prevent doubling of the chromosome number 3 reduce the chances of mutation A 1 only B 2 only C 2 and 3 only D 1, 2 and 3

1 marks

Answer: B

This question in 9700/11 May/June 2012

Q38 · What are the conditions in a human cell just before the cell enters prophase? 9700/11 May/June 2012

19 What are the conditions in a human cell just before the cell enters prophase? number of number of molecules nuclear envelope spindle present chromatids of DNA in nucleus present A 46 46 yes no B 92 46 no yes C 46 92 yes yes D 92 92 no yes

1 marks

Answer: D

This question in 9700/11 May/June 2012

Q39 · The diagram shows the cell cycle 9700/12 May/June 2012

18 The diagram shows the cell cycle. When radioactive nucleotides are supplied to dividing cells, at which point will they be incorporated into the chromosomes? mitosis B C D A interphase

1 marks

Answer: A

This question in 9700/12 May/June 2012

Q40 · For organisms undergoing sexual reproduction, a reduction division occurs before… 9700/13 May/June 2012

20 For organisms undergoing sexual reproduction, a reduction division occurs before fertilisation. Which reasons explain why this is necessary? 1 increase genetic variation 2 prevent doubling of the chromosome number 3 reduce the chances of mutation A 1 only B 2 only C 2 and 3 only D 1, 2 and 3

1 marks

Answer: B

This question in 9700/13 May/June 2012

Q41 · What are the conditions in a human cell just before the cell enters prophase? 9700/13 May/June 2012

22 What are the conditions in a human cell just before the cell enters prophase? number of number of molecules nuclear envelope spindle present chromatids of DNA in nucleus present A 46 46 yes no B 92 46 no yes C 46 92 yes yes D 92 92 no yes

1 marks

Answer: D

This question in 9700/13 May/June 2012

Q42 · Which statement is incorrect for mitotic cell division? 9700/11 Oct/Nov 2012

18 Which statement is incorrect for mitotic cell division? A DNA is replicated semi-conservatively during mitosis. B DNA is normally unchanged from one generation of cells to the next. C The daughter cells have the potential to produce the same enzymes as the parent cell. D The same quantity of DNA is distributed to the nuclei of two new cells.

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2012

Q43 · Immediately after which stage in mitosis in an animal cell does the cytoplasm start to… 9700/12 Oct/Nov 2012

19 Immediately after which stage in mitosis in an animal cell does the cytoplasm start to divide? A anaphase B metaphase C prophase D telophase

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2012

Q44 · Colchicine is a substance which inhibits the formation of spindle fibres 9700/13 Oct/Nov 2012

18 Colchicine is a substance which inhibits the formation of spindle fibres. At which stage is the cell cycle interrupted? A cell division B DNA replication C interphase D mitosis

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2012

Q45 · Which statement describes a cell belonging to a haploid organism that is capable of… 9700/11 May/June 2013

19 Which statement describes a cell belonging to a haploid organism that is capable of reproduction? A It has chromosomes that contain one polynucleotide chain. B It is capable of carrying out a reduction division to form gametes. C It possesses two copies of each gene as a result of fertilisation. D It will undergo cell division by mitosis during asexual reproduction.

1 marks

Answer: D

This question in 9700/11 May/June 2013

Q46 · Some chemicals, used to stop tumour growth, work by preventing the DNA double helix from… 9700/11 May/June 2013

20 Some chemicals, used to stop tumour growth, work by preventing the DNA double helix from uncoiling and separating. During which stage of the cell cycle would they act? A anaphase B interphase C metaphase D prophase

1 marks

Answer: B

This question in 9700/11 May/June 2013

Q47 · Chromosome telomeres are essential for DNA replication and are not completely replaced… 9700/12 May/June 2013

19 Chromosome telomeres are essential for DNA replication and are not completely replaced during mitosis. A substance X is known that completely replaces telomeres during mitosis. What will be the effect of growing cells with and without substance X? with substance X without substance X A cells divide continually cell division eventually slows and stops B cells divide more rapidly cells divide continually C cell division eventually slows cell division stops immediately and stops D cell division stops immediately cells divide continually

1 marks

Answer: A

This question in 9700/12 May/June 2013

Q48 · The diagram shows a cell nucleus in prophase of mitosis 9700/12 May/June 2013

20 The diagram shows a cell nucleus in prophase of mitosis. Which statement describes the chromosomes found in each daughter nucleus immediately following division of this cell by mitosis? A 8 chromosomes, each consisting of 4 chromatids B 8 chromosomes, each containing 1 molecule of DNA C 4 chromosomes, each consisting of 4 chromatids D 16 chromosomes, each containing 1 molecule of DNA

1 marks

Answer: B

This question in 9700/12 May/June 2013

Q49 · Which features of mitosis ensure that the genetic constitution of the cell is maintained? 9700/12 May/June 2013

21 Which features of mitosis ensure that the genetic constitution of the cell is maintained? 1 the position of the chromosomes on the equator of the spindle 2 the longitudinal division of the centromeres 3 the DNA of the parent cells replicates before mitosis begins 4 the pulling apart of the chromatids to opposite poles A 1, 2 and 3 only B 1, 2 and 4 only C 2, 3 and 4 only D 1, 2, 3 and 4

1 marks

Answer: C

This question in 9700/12 May/June 2013

Q50 · Uncontrolled cell division of cancer cells forms tumours 9700/13 May/June 2013

19 Uncontrolled cell division of cancer cells forms tumours. Which statement describes the difference between a cancer cell and a normal cell? A Cancer cells do not undergo cytokinesis. B Cancer cells do not have metaphase. C Cancer cells have a shorter interphase. D Only cancer cells have mutated DNA.

1 marks

Answer: C

This question in 9700/13 May/June 2013

Q51 · Exposure to which of the following increases the risk of developing a cancerous growth? 9700/11 Oct/Nov 2013

17 Exposure to which of the following increases the risk of developing a cancerous growth? ultraviolet viruses carbon X-rays light monoxide y v x key JY increases risk Jv Jv x Jv X does not increase risk Jv Jv

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2013

Q52 · The diagram shows an outline of the process of sexual reproduction 9700/11 Oct/Nov 2013

18 The diagram shows an outline of the process of sexual reproduction. adult cell adult cell 1 1 gamete P gamete fertilisation Q zygote 2 fetus Which row identifies the type of cell division occurring during stages 1 and 2 and the number of chromosomes in cells P and Q? 1 2 P Q A meiosis meiosis diploid haploid B meiosis mitosis haploid diploid C mitosis meiosis haploid diploid D mitosis mitosis diploid haploid

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2013

Q53 · What correctly describes the effect of carcinogens on lung tissue? 9700/11 Oct/Nov 2013

31 What correctly describes the effect of carcinogens on lung tissue? A Cells of the alveoli walls divide more rapidly than normal by reduction division causing a tumour to develop. B Cilia are paralysed and mucus accumulates in the lungs, causing DNA to change and a tumour to develop. C DNA changes, causing bronchial epithelial cells to divide by mitosis in an uncontrolled way, causing a tumour to develop. D Haemoglobin carries less oxygen, causing bronchial cells to divide by mitosis in an uncontrolled way, causing a tumour to develop.

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2013

Q54 · Which statements about cancer are correct? 9700/12 Oct/Nov 2013

17 Which statements about cancer are correct? 1 Exposure to UV light from the sun always causes skin cancer. 2 Some viruses can cause cancer. 3 The mutation of genes controlling the cell cycle may cause cancer. A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2013

Q55 · The diagram represents the life cycle of a sexually reproducing animal 9700/12 Oct/Nov 2013

18 The diagram represents the life cycle of a sexually reproducing animal. n n 3 4 1 2 2n 2n 2n n n Which row correctly identifies meiosis and mitosis? meiosis mitosis A 1 4 B 2 1 C 3 2 D 4 3

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2013

Q56 · The diagram shows part of the life cycle of the honey bee, Apis mellifera 9700/13 Oct/Nov 2013

17 The diagram shows part of the life cycle of the honey bee, Apis mellifera. 2 unfertilised male drones 1 (n = 16) queen gametes (2n = 32) (n = 16) 3 fertilised female workers (2n = 32) Where does mitosis occur? A 1 only B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2013

Q57 · Which processes occur by mitosis? 9700/11 May/June 2014

18 Which processes occur by mitosis? 1 cloning of plasma cells 2 gamete production 3 replacing damaged cells A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: B

This question in 9700/11 May/June 2014

Q58 · The diagram shows crosses between wild wheat and two types of grass 9700/11 May/June 2014

19 The diagram shows crosses between wild wheat and two types of grass. wild wheat × goat grass 2n = 14 2n = 14 sterile hybrid mutation doubles chromosome number fertile hybrid 1 × another grass 2n = 14 sterile hybrid mutation doubles chromosome number fertile hybrid 2 What is the chromosome number of the fertile hybrid 2? A 28 B 42 C 56 D 140

1 marks

Answer: B

This question in 9700/11 May/June 2014

Q59 · The cell cycle includes mitosis 9700/12 May/June 2014

17 The cell cycle includes mitosis. Which are features of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically identical cells 3 semi-conservative replication of DNA A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only

1 marks

Answer: D

This question in 9700/12 May/June 2014

Q60 · Which is the correct statement concerning cell and nuclear division? 9700/12 May/June 2014

18 Which is the correct statement concerning cell and nuclear division? A Haploid eukaryotes can reproduce by mitosis whereas diploid eukaryotes can reproduce by mitosis or meiosis. B Just before prophase, the mass of DNA is double the normal mass. Following anaphase, this mass is reduced by half and following cytokinesis this mass halves again. C Mutagens can cause mutations whereas carcinogens can cause cancer. This means that all mutagens are carcinogenic. D Some of the roles of mitosis are growth, asexual reproduction, cell repair following tissue damage and cell replacement.

1 marks

Answer: A

This question in 9700/12 May/June 2014

Q61 · During which process does only mitosis occur? 9700/13 May/June 2014

19 During which process does only mitosis occur? A the production of antibodies from B-lymphocyte memory cells B the production of cancerous tissue in alveoli C the production of gametes D the production of root hairs

1 marks

Answer: B

This question in 9700/13 May/June 2014

Q62 · Which statement about a diploid cell is not correct? 9700/11 Oct/Nov 2014

16 Which statement about a diploid cell is not correct? A It can undergo a mitotic division to allow growth to occur. B It can undergo a mitotic division to repair a cell. C It can undergo a reduction division to form haploid cells. D It is one that possesses two complete sets of chromosomes.

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2014

Q63 · Laboratory mice whose p53 genes had been switched off developed tumours 9700/11 Oct/Nov 2014

17 Laboratory mice whose p53 genes had been switched off developed tumours. When their p53 genes were switched on again, the tumour cells stopped dividing and died within a few days. Healthy cells in the mice were unaffected. What do these observations suggest? A p53 protein speeds up the mitotic cell cycle B p53 protein causes all cells to die C the p53 gene acts as a tumour suppressor gene D the p53 gene encourages the growth of tumours

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2014

Q64 · A student examined the cells in the growing region (meristem) of an onion root and… 9700/12 Oct/Nov 2014

19 A student examined the cells in the growing region (meristem) of an onion root and obtained the data below. stage number of cells interphase 886 prophase 73 metaphase 16 anaphase 14 telophase 11 What percentage of cells contain chromosomes that appear as two chromatids? A 97.5 % B 95.9 % C 8.9 % D 7.3 %

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2014

Q65 · Which definitions of diploid and haploid are true for typical eukaryotic cells? 9700/12 Oct/Nov 2014

20 Which definitions of diploid and haploid are true for typical eukaryotic cells? 1 diploid – any cell with an even number of homologous chromosomes 2 diploid – any cell with two copies of each homologous chromosome 3 haploid – any cell with half the diploid number of homologous chromosomes 4 haploid – any cell with one copy of each homologous chromosome A 1 and 3 B 1 and 4 C 2 and 3 D 2 and 4

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2014

Q66 · Which is always true of cytokinesis? 9700/13 Oct/Nov 2014

17 Which is always true of cytokinesis? 1 Cell structures replicate. 2 Cell structures are divided between two cells. 3 Nuclear envelope reforms. A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: C

This question in 9700/13 Oct/Nov 2014

Q67 · The graphs show various measurements taken from metaphase of mitosis onwards 9700/11 May/June 2015

18 The graphs show various measurements taken from metaphase of mitosis onwards. The graphs are to scale when compared to one another. X distance time Y distance time Z distance time Which row correctly identifies each graph? X Y Z A distance between poles distance between distance of centromere of spindle sister chromatids from pole of spindle B distance between poles distance of centromere distance between of spindle from pole of spindle sister chromatids C distance of centromere distance between distance between from pole of spindle poles of spindle sister chromatids D distance of centromere distance between distance between poles from pole of spindle sister chromatids of spindle

1 marks

Answer: C

This question in 9700/11 May/June 2015

Q68 · A scientist counted 22 chromosomes in each of the root cells of a xerophytic plant 9700/11 May/June 2015

19 A scientist counted 22 chromosomes in each of the root cells of a xerophytic plant. What is the diploid and haploid number of chromosomes for this species? diploid haploid number number A 11 22 B 22 11 C 22 44 D 44 22

1 marks

Answer: B

This question in 9700/11 May/June 2015

Q69 · Which diagrams show the correct relationships? 9700/13 May/June 2015

19 Which diagrams show the correct relationships? conservation increase in DNA A of chromosome mitosis 2n n chromosome 2n 4n replication number number increase in reduction in DNA B chromosome 2n 2n chromosome meiosis 2n n replication number number increase in reduction in DNA C chromosome n 2n chromosome mitosis 2n n replication number number reduction in conservation D chromosome meiosis 2n n of chromosome mitosis 2n 2n number number

1 marks

Answer: D

This question in 9700/13 May/June 2015

Q70 · The diagram represents stages in the life cycle of an organism 9700/11 Oct/Nov 2015

19 The diagram represents stages in the life cycle of an organism. cells of P cells of gamete gamete parent 1 parent 2 Q zygote R adult Which arrow represents a process that results in haploid cells and which represents mitosis? produces mitosis haploid cells A P Q B Q R C R Q D P R

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2015

Q71 · Which statements about a diploid cell are correct? 9700/12 Oct/Nov 2015

18 Which statements about a diploid cell are correct? 1 can divide by mitosis to repair itself 2 has two complete sets of chromosomes 3 can undergo a reduction division to form haploid cells 4 can undergo mitotic division to allow growth to occur A 1, 2 and 3 B 1, 2 and 4 C 1, 3 and 4 D 2, 3 and 4

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2015

Q72 · Which metabolic processes will be very active in a cell that has just completed… 9700/12 Oct/Nov 2015

19 Which metabolic processes will be very active in a cell that has just completed cytokinesis? 1 ATP formation 2 DNA replication 3 protein synthesis A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2015

Q73 · Which row shows the products of mitosis, reduction division (meiosis) and fertilisation? 9700/13 Oct/Nov 2015

19 Which row shows the products of mitosis, reduction division (meiosis) and fertilisation? products products of product of of mitosis meiosis fertilisation A four diploid cells two diploid cells diploid cell B four haploid cells four diploid cells haploid cell C two diploid cells four haploid cells diploid cell D two diploid cells two haploid cells haploid cell

1 marks

Answer: C

This question in 9700/13 Oct/Nov 2015

Q74 · Which statements about the cell cycle are correct? 9700/12 Feb/March 2016

16 Which statements about the cell cycle are correct? 1 The cell cycle consists of both interphase and mitosis. 2 DNA replication takes place in interphase. 3 A cell can remain in interphase for several months. A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/12 Feb/March 2016

Q75 · The protein p53 is produced in a cell in response to DNA damage 9700/11 May/June 2016

18 The protein p53 is produced in a cell in response to DNA damage. This protein stops the cell cycle for a short time just before the DNA is replicated, so that the DNA can be repaired. At which phase of the cell cycle will this stop occur? A M B G1 C S D G2

1 marks

Answer: B

This question in 9700/11 May/June 2016

Q76 · Which feature of stem cells enables them to replace cells in tissues such as the skin? 9700/11 May/June 2016

19 Which feature of stem cells enables them to replace cells in tissues such as the skin? A They are undifferentiated cells that are present at birth. B They differentiate to form skin cells. C They divide by mitosis to supply some cells that can differentiate. D They have the full number of chromosomes.

1 marks

Answer: C

This question in 9700/11 May/June 2016

Q77 · Mitosis is an important process for organisms 9700/12 May/June 2016

18 Mitosis is an important process for organisms. Which features of mitosis are important for single-celled organisms? 1 asexual reproduction 2 growth 3 production of genetically identical cells A 1, 2 and 3 B 1 and 3 only C 2 and 3 only D 1 only

1 marks

Answer: B

This question in 9700/12 May/June 2016

Q78 · Which processes occur in bone marrow cells that are in a mitotic cell cycle? 9700/13 May/June 2016

18 Which processes occur in bone marrow cells that are in a mitotic cell cycle? 1 phosphate groups bind to ADP molecules to form ATP 2 bonds form between nucleotides in a DNA strand 3 tRNA anticodons hydrogen bond with codons on mRNA A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only

1 marks

This question in 9700/13 May/June 2016

Q79 · Which event is part of the mitotic cell cycle? 9700/11 Oct/Nov 2016

18 Which event is part of the mitotic cell cycle? A anaphase B cytokinesis C DNA replication D interphase

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2016

Q80 · Chromosome telomeres are essential for DNA replication and are not completely replaced… 9700/13 Oct/Nov 2016

17 Chromosome telomeres are essential for DNA replication and are not completely replaced during mitosis. Substance X completely replaces telomeres during mitosis. What will be the effect of growing cells with and without substance X? with substance X without substance X A cells divide continually cell division eventually slows and stops B cells divide more rapidly cells divide continually C cell division eventually slows cell division stops immediately and stops D cell division stops immediately cells divide continually

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2016

Q81 · Some stem cells divide and give rise to phagocytes 9700/12 Feb/March 2017

20 Some stem cells divide and give rise to phagocytes. Where in the human body do these stem cells divide? 1 blood 2 bone marrow 3 lymph nodes A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: C

This question in 9700/12 Feb/March 2017

Q82 · What is the correct sequence of stages in the mitotic cell cycle? 9700/12 Feb/March 2017

21 What is the correct sequence of stages in the mitotic cell cycle? A G1 → G2 → mitosis → S → cytokinesis B G1 → G2 → S → mitosis → cytokinesis C G1 → S → G2 → mitosis → cytokinesis D S → G1 → mitosis → G2 → cytokinesis

1 marks

Answer: C

This question in 9700/12 Feb/March 2017

Q83 · The enzyme telomerase repairs telomeres 9700/12 Feb/March 2017

22 The enzyme telomerase repairs telomeres. It stops the telomeres from getting shorter each time a chromosome is replicated. Telomerase is not normally active in human body cells, but in some diseases telomerase can be activated. In which disease is the enzyme telomerase activated? A cancer B HIV/AIDS C malaria D myasthenia gravis

1 marks

Answer: A

This question in 9700/12 Feb/March 2017

Q84 · Bacterial cells divide by a process called binary fission 9700/11 May/June 2017

13 Bacterial cells divide by a process called binary fission. Which macromolecules must be synthesised for binary fission? 1 cell membrane proteins and RNA 2 DNA and peptidoglycan 3 enzymes and cellulose A 1, 2 and 3 B 1 and 2 only C 2 and 3 only D 3 only

1 marks

Answer: B

This question in 9700/11 May/June 2017

Q85 · The diagram shows the mitotic cell cycle 9700/11 May/June 2017

21 The diagram shows the mitotic cell cycle. During which phase is DNA replicated? cell division D C B A

1 marks

Answer: B

This question in 9700/11 May/June 2017

Q86 · The diagram shows the cell cycle of a mammalian cell 9700/13 May/June 2017

16 The diagram shows the cell cycle of a mammalian cell. G2 M S cytokinesis G1 Checkpoints in the cell cycle of mammals prevent the cycle from continuing when mistakes are made or DNA is damaged. Four of the checkpoints are described. 1 Mitosis is blocked if DNA replication is incomplete. 2 Anaphase is blocked if the assembly of chromatids on the spindle is unsuccessful. 3 DNA replication is blocked if DNA is damaged. 4 DNA replication stops if damage to DNA has not been repaired. In which phases of the cell cycle do these checkpoints occur? checkpoint 1 2 3 4 A M G1 S G2 B G2 M G1 S C G2 S G1 M D S G2 M G1

1 marks

Answer: B

This question in 9700/13 May/June 2017

Q87 · The photomicrographs show cells in various stages of the cell cycle 9700/12 Oct/Nov 2017

19 The photomicrographs show cells in various stages of the cell cycle. In which stage does semi-conservative replication of DNA take place? A B C D

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2017

Q88 · Cancer cells may divide by far more divisions than other cells found in humans 9700/12 Oct/Nov 2017

21 Cancer cells may divide by far more divisions than other cells found in humans. Which statement about cancer cells is correct? A They are able to synthesise the enzyme telomerase. B They have a mutation in the telomeres so DNA is not hydrolysed. C They have DNA polymerase so can replicate their DNA without telomere loss. D They increase the number of copies of repeated DNA sequences in the telomeres.

1 marks

Answer: A

This question in 9700/12 Oct/Nov 2017

Q89 · Uncontrolled cell division can form tumours 9700/13 Oct/Nov 2017

21 Uncontrolled cell division can form tumours. Which statement is correct for tumour cells only? A Metaphase does not take place. B Cytokinesis does not occur. C Interphase takes less time. D They have mutated DNA.

1 marks

Answer: C

This question in 9700/13 Oct/Nov 2017

Q90 · Which of these events are part of mitosis? 9700/13 Oct/Nov 2017

22 Which of these events are part of mitosis? 1 interphase 2 anaphase 3 cytokinesis A 1, 2 and 3 B 1 and 3 only C 1 only D 2 only

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2017

Q91 · Which of these processes will require ATP? 9700/12 Feb/March 2018

6 Which of these processes will require ATP? 1 transport of water in the xylem 2 semi-conservative replication of DNA 3 facilitated diffusion of amino acids into the cell A 1, 2 and 3 B 1 and 2 only C 2 and 3 only D 2 only

1 marks

Answer: D

This question in 9700/12 Feb/March 2018

Q92 · How many copies of each different DNA molecule will be found in a cell at the start of… 9700/12 Feb/March 2018

20 How many copies of each different DNA molecule will be found in a cell at the start of each of these stages of the mitotic cell cycle? G2 of prophase cytokinesis interphase A 1 1 2 B 1 2 1 C 2 1 2 D 2 2 2

1 marks

Answer: D

This question in 9700/12 Feb/March 2018

Q93 · A student observed the cells in the growing region (meristem) of an onion root and… 9700/11 May/June 2018

18 A student observed the cells in the growing region (meristem) of an onion root and obtained the data shown. stage number of cells interphase 886 prophase 73 metaphase 16 anaphase 14 telophase 11 Which percentage of cells contains chromosomes that appear as two chromatids? A 7.3 B 8.9 C 95.9 D 97.5

1 marks

Answer: B

This question in 9700/11 May/June 2018

Q94 · Which of these events are part of mitosis? 9700/11 May/June 2018

19 Which of these events are part of mitosis? 1 interphase 2 telophase 3 cytokinesis A 1, 2 and 3 B 1 and 3 only C 1 only D 2 only

1 marks

Answer: D

This question in 9700/11 May/June 2018

Q95 · During which phase of the cell cycle does DNA replication take place? 9700/11 May/June 2018

20 During which phase of the cell cycle does DNA replication take place? A G1 B G2 C M D S

1 marks

Answer: D

This question in 9700/11 May/June 2018

Q96 · One of the chromosomes in a nucleus has a telomere which contains many repeats of the… 9700/12 May/June 2018

18 One of the chromosomes in a nucleus has a telomere which contains many repeats of the base sequence TTAGGG. This chromosome was extracted from four different cells and the total number of bases in the telomere was determined. Which total number of bases was found in the cell that had undergone the most mitotic divisions? A 5548 B 5580 C 5645 D 5700

1 marks

Answer: A

This question in 9700/12 May/June 2018

Q97 · Which of these statements about cytokinesis is always true? 9700/12 May/June 2018

20 Which of these statements about cytokinesis is always true? 1 Cell structures replicate. 2 Cell structures are shared between two cells. 3 Nuclear envelope reforms. A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: C

This question in 9700/12 May/June 2018

Q98 · Which features of an organism are affected by a drug that stops mitosis? 9700/13 May/June 2018

19 Which features of an organism are affected by a drug that stops mitosis? 1 cell repair 2 cell replacement 3 number of stem cells 4 tissue repair 5 tumour formation A 1, 2, 3, 4 and 5 B 1, 2 and 3 only C 1, 4 and 5 only D 2, 3, 4 and 5 only

1 marks

Answer: D

This question in 9700/13 May/June 2018

Q99 · How many copies of each DNA molecule will be found in a cell at each stage of the mitotic… 9700/11 Oct/Nov 2018

19 How many copies of each DNA molecule will be found in a cell at each stage of the mitotic cell cycle? G1 of cytokinesis interphase A 1 1 B 1 2 C 2 1 D 2 2

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2018

Q100 · Which metabolic processes will be very active in a cell that has just completed… 9700/11 Oct/Nov 2018

20 Which metabolic processes will be very active in a cell that has just completed cytokinesis? 1 ATP formation 2 DNA replication 3 protein synthesis A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2018

Q101 · A mutation occurs in a gene which prevents the production of telomerase 9700/11 Oct/Nov 2018

21 A mutation occurs in a gene which prevents the production of telomerase. What is the effect of this mutation if it occurs in bone marrow stem cells? A a rapid increase in the production of lymphocytes B a tumour grows in the bone marrow C bone marrow stem cells eventually no longer divide D the total blood cell count will be unchanged

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2018

Q102 · The photomicrograph shows cells in different stages of mitosis 9700/12 Oct/Nov 2018

20 The photomicrograph shows cells in different stages of mitosis. P T Q S R Which statements are correct? 1 Cell T shows metaphase. 2 DNA replication occurs in cell R. 3 The amount of DNA in cell P is the same as in cell T. 4 The correct order for the stages is S → R → T → P → Q. A 1, 2 and 3 B 1, 2 and 4 C 1, 3 and 4 D 2, 3 and 4

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2018

Q103 · Which changes in a group of mammalian cells, dividing by mitosis, would be necessary for… 9700/12 Oct/Nov 2018

21 Which changes in a group of mammalian cells, dividing by mitosis, would be necessary for the formation of a tumour? 1 Mitosis is no longer inhibited by cell to cell contact. 2 Cells acquire the ability to migrate and set up new colonies. 3 Cells become able to divide indefinitely. A 1 and 2 B 1 and 3 C 1 only D 2 and 3

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2018

Q104 · How many copies of each DNA molecule will be found in a cell at each stage of the mitotic… 9700/13 Oct/Nov 2018

20 How many copies of each DNA molecule will be found in a cell at each stage of the mitotic cell cycle? G2 of metaphase cytokinesis interphase A 1 1 1 B 1 2 2 C 2 1 1 D 2 2 2

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2018

Q105 · Embryonic stem cells are able to replicate continuously 9700/12 Feb/March 2019

20 Embryonic stem cells are able to replicate continuously. What happens to the telomeres during repeated mitotic cell cycles of embryonic stem cells? A Their lengths increase. B Their lengths decrease. C They are completely lost. D They stay the same length.

1 marks

Answer: D

This question in 9700/12 Feb/March 2019

Q106 · Which events listed are part of mitosis? 9700/11 May/June 2019

20 Which events listed are part of mitosis? 1 interphase 2 prophase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 only D 2 only

1 marks

Answer: D

This question in 9700/11 May/June 2019

Q107 · The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles 9700/12 May/June 2019

16 The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells need to transcribe telomerase enzyme? 1 cancer cells 2 stem cells 3 activated memory B-lymphocytes A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/12 May/June 2019

Q108 · The diagram shows some of the stages which take place during the cell cycle 9700/12 May/June 2019

17 The diagram shows some of the stages which take place during the cell cycle. 1 number of DNA molecules in cell doubles 4 stages 2 nuclear envelope during cell cell grows disappears cycle 3 chromosomes become visible Which two stages take place during interphase? A 1 and 2 B 1 and 3 C 2 and 4 D 3 and 4

1 marks

Answer: A

This question in 9700/12 May/June 2019

Q109 · The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles 9700/13 May/June 2019

22 The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells need to transcribe telomerase enzyme? 1 stem cells 2 activated memory B-lymphocytes 3 helper T-lymphocytes secreting cytokines A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: B

This question in 9700/13 May/June 2019

Q110 · A gene codes for the production of a protein, p53, that binds to damaged DNA during… 9700/13 May/June 2019

24 A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase and prevents its replication. A carcinogen in cigarette smoke mutates this gene. Which statement explains why this mutation may cause cancer? A Cells with no p53 are allowed to undergo mitosis. B Cells with no p53 allow their damaged DNA to replicate. C The carcinogen in cigarette smoke increases the rate of cell division. D The p53 causes uncontrolled cell division.

1 marks

Answer: B

This question in 9700/13 May/June 2019

Q111 · The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles 9700/11 Oct/Nov 2019

19 The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells transcribe a high concentration of telomerase? 1 neutrophils 2 mature red blood cells 3 activated memory T-lymphocytes A 1 and 2 B 1 and 3 only C 1 only D 3 only

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2019

Q112 · The cell cycle includes mitosis 9700/12 Oct/Nov 2019

21 The cell cycle includes mitosis. Which are features of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically identical nuclei 3 semi-conservative replication of DNA A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2019

Q113 · The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles 9700/12 Oct/Nov 2019

39 The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which types of white blood cell involved in an autoimmune condition will contain active telomerase? mature helper B-lymphocyte neutrophils T-lymphocyte plasma cells memory cells v Jv J key Jv Jv x / =contain active telomerase x x v X = do not contain active telomerase x Jv Jv

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2019

Q114 · Which processes that occur in cell division are represented in the diagram? 9700/13 Oct/Nov 2019

17 Which processes that occur in cell division are represented in the diagram? 4 3 mass of nuclear DNA in a cell 2 / arbitrary units 1 0 time A DNA replication and nuclear division only B DNA replication, nuclear division and cytokinesis C mitosis and cytokinesis D mitosis only

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2019

Q115 · What happens to the telomeres during mitosis of a cancer cell? 9700/13 Oct/Nov 2019

18 What happens to the telomeres during mitosis of a cancer cell? A The length increases. B The length decreases. C They are completely lost. D They stay the same length.

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2019

Q116 · The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles 9700/13 Oct/Nov 2019

39 The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Three types of cell are used to produce monoclonal antibodies. 1 cancer cells undergoing uncontrolled cell division 2 mature B-lymphocytes 3 hybridoma cells Which cells involved in this technique contain active telomerase enzyme? A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: C

This question in 9700/13 Oct/Nov 2019

Q117 · Which cells contain telomeres that are longer than those in a helper T-lymphocyte… 9700/12 Feb/March 2020

19 Which cells contain telomeres that are longer than those in a helper T-lymphocyte secreting cytokines? 1 bone marrow stem cells 2 mature red blood cells 3 activated memory B-lymphocytes A 1 and 2 B 1 and 3 C 2 only D 3 only

1 marks

Answer: B

This question in 9700/12 Feb/March 2020

Q118 · In which stage of the cell cycle are telomeres needed to prevent the loss of genes? 9700/12 Feb/March 2020

20 In which stage of the cell cycle are telomeres needed to prevent the loss of genes? A prophase B cytokinesis C G1 phase D S phase

1 marks

Answer: D

This question in 9700/12 Feb/March 2020

Q119 · Which feature of stem cells enables them to replace cells in tissues such as the skin? 9700/11 May/June 2020

17 Which feature of stem cells enables them to replace cells in tissues such as the skin? A They are undifferentiated cells that are present at birth. B They differentiate to form skin cells. C They divide by mitosis to supply some cells that can differentiate. D They have the full number of chromosomes.

1 marks

Answer: C

This question in 9700/11 May/June 2020

Q120 · The diagram shows the cell cycle 9700/11 May/June 2020

19 The diagram shows the cell cycle. During which phase do chromosomes condense and become visible? cytokinesis D C A B

1 marks

Answer: D

This question in 9700/11 May/June 2020

Q121 · Which processes involve mitosis? 9700/12 May/June 2020

20 Which processes involve mitosis? clonal selection forming cells at the of T-lymphocytes tip of a growing root B A C D replacing skin cells damaged by an injury

1 marks

Answer: C

This question in 9700/12 May/June 2020

Q122 · The diagram shows the relative time taken for each stage in the cell cycle 9700/13 May/June 2020

18 The diagram shows the relative time taken for each stage in the cell cycle. X Y Z Which row identifies the correct sequence of the stages in the cell cycle? cytokinesis interphase mitosis A X Y Z B X Z Y C Y Z X D Z X Y

1 marks

Answer: C

This question in 9700/13 May/June 2020

Q123 · The electron micrograph shows a cell structure in a eukaryotic cell 9700/11 Oct/Nov 2020

4 The electron micrograph shows a cell structure in a eukaryotic cell. Which statements about this cell structure are correct? 1 ATP is synthesised in this cell structure. 2 The cell structure is made of protein molecules. 3 The cell structure replicates during interphase of the cell cycle. A 1 and 2 B 1 and 3 C 2 and 3 D 3 only

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2020

Q124 · Methotrexate is a drug used to treat cancer 9700/11 Oct/Nov 2020

19 Methotrexate is a drug used to treat cancer. It can act as an enzyme inhibitor preventing the synthesis of nucleotides containing thymine. Cells treated with methotrexate are not able to complete the cell cycle. A cell entering telophase is treated with methotrexate. Which stage of the cell cycle will be affected by the action of methotrexate? A anaphase B interphase C metaphase D prophase

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2020

Q125 · Which features of mitosis are important for a single-celled organism? 9700/13 Oct/Nov 2020

20 Which features of mitosis are important for a single-celled organism? 1 asexual reproduction 2 production of genetically identical cells 3 growth A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2020

Q126 · Some events in the cell cycle are listed 9700/13 Oct/Nov 2020

21 Some events in the cell cycle are listed. Which events are part of mitosis? 1 interphase 2 metaphase 3 cytokinesis A 1, 2 and 3 B 1 and 3 only C 1 only D 2 only

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2020

Q127 · Which letter identifies cell structures where semi-conservative replication of DNA occurs? 9700/12 Feb/March 2021

3 Which letter identifies cell structures where semi-conservative replication of DNA occurs? chloroplasts B A mitochondria nuclei D C

1 marks

Answer: A

This question in 9700/12 Feb/March 2021

Q128 · Which statements about mitosis are correct? 9700/12 Feb/March 2021

19 Which statements about mitosis are correct? 1 Mitosis results in genetically identical cells. 2 Mitosis is involved in asexual reproduction. 3 Mitosis occurs immediately after cytokinesis. 4 Mitosis can be used to repair damaged cells. A 1, 2, 3 and 4 B 1, 2 and 4 only C 1 and 2 only D 3 and 4 only

1 marks

Answer: C

This question in 9700/12 Feb/March 2021

Q129 · The jellyfish, Turritopsis dohrnii, is described as being immortal 9700/11 May/June 2021

18 The jellyfish, Turritopsis dohrnii, is described as being immortal. If T. dohrnii is not eaten by predators or diseased, it seems to be able to live forever. There is no way to determine the biological age of a T. dohrnii individual. Which feature of the cells in T. dohrnii could explain these observations? A very long G phases in the cell cycle B a very short S phase in the cell cycle C an ability to restore telomeres to their original length D fewer chromosomes than other eukaryotic organisms

1 marks

Answer: C

This question in 9700/11 May/June 2021

Q130 · Some chemicals, used to stop tumour growth, work by preventing the DNA double helix from… 9700/11 May/June 2021

19 Some chemicals, used to stop tumour growth, work by preventing the DNA double helix from uncoiling and separating. During which stage of the cell cycle would they act? A anaphase B interphase C metaphase D prophase

1 marks

Answer: B

This question in 9700/11 May/June 2021

Q131 · The diagram represents the cell cycle of a human cell 9700/12 May/June 2021

18 The diagram represents the cell cycle of a human cell. During the cell cycle the number of chromatids changes. mitosis G2 M S C cytokinesis G1 Which row is correct for the number of chromatids in M, G1, and G2? M G1 G2 A 46 46 92 B 46 92 92 C 92 46 92 D 92 92 92

1 marks

Answer: C

This question in 9700/12 May/June 2021

Q132 · A single skin cell was isolated and transferred to growth medium in a sterile Petri dish 9700/12 May/June 2021

19 A single skin cell was isolated and transferred to growth medium in a sterile Petri dish. The Petri dish was incubated for 16 days. During this time, the number of skin cells multiplied as a result of repeated mitotic divisions. One of the chromosomes in the nucleus of each skin cell has a telomere that contains many repeats of the base sequence TTAGGG. On each of days 4, 8, 12 and 16 of the incubation period, a single cell was removed from the Petri dish. The total number of bases in the telomere of this chromosome was determined for each cell. Each of the four cells had a different total number of telomere bases for this chromosome: 5548, 5580, 5645 and 5700. What was the total number of telomere bases in the chromosome from the cell that had undergone the most mitotic divisions? A 5548 B 5580 C 5645 D 5700

1 marks

Answer: A

This question in 9700/12 May/June 2021

Q133 · How many copies of each different DNA molecule are found in a cell at the start of each… 9700/13 May/June 2021

18 How many copies of each different DNA molecule are found in a cell at the start of each of these stages of the mitotic cell cycle? G2 of prophase cytokinesis interphase A 1 1 2 B 1 2 1 C 2 1 2 D 2 2 2

1 marks

Answer: D

This question in 9700/13 May/June 2021

Q134 · Hydra are simple animals which can reproduce asexually 9700/13 May/June 2021

19 Hydra are simple animals which can reproduce asexually. The photomicrograph shows an adult hydra with a new hydra developing while attached to the side of the adult animal. Which processes have occurred in the two hydra? 1 DNA replication 2 growth 3 mitosis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/13 May/June 2021

Q135 · What will be present in each chromosome at the end of the G2 phase of the cell cycle? 9700/11 Oct/Nov 2021

17 What will be present in each chromosome at the end of the G2 phase of the cell cycle? A two centrioles B two centromeres C two molecules of DNA D two telomeres

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2021

Q136 · Which events listed are part of the cell cycle? 9700/11 Oct/Nov 2021

18 Which events listed are part of the cell cycle? 1 interphase 2 metaphase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2021

Q137 · Which features of an organism are affected by a drug that kills cells that are dividing… 9700/11 Oct/Nov 2021

19 Which features of an organism are affected by a drug that kills cells that are dividing mitotically? 1 cell repair 2 cell replacement 3 number of stem cells 4 tissue repair 5 tumour formation A 1, 2, 3, 4 and 5 B 1, 2 and 3 only C 1, 4 and 5 only D 2, 3, 4 and 5 only

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2021

Q138 · The photomicrographs show cells in various stages of the cell cycle 9700/12 Oct/Nov 2021

20 The photomicrographs show cells in various stages of the cell cycle. 1 2 3 4 Which cells contain twice as many DNA molecules as a cell from the same organism that has just finished a complete mitotic cell cycle ending with cytokinesis? A 1, 2, 3 and 4 B 1, 2 and 4 only C 1 and 3 only D 2 and 4 only

1 marks

Answer: A

This question in 9700/12 Oct/Nov 2021

Q139 · Uncontrolled cell division can result in the formation of a tumour 9700/12 Oct/Nov 2021

21 Uncontrolled cell division can result in the formation of a tumour. Which part of the cell cycle would take less time during the formation of a tumour? A cytokinesis B interphase C mitosis D telophase

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2021

Q140 · Some processes are listed 9700/13 Oct/Nov 2021

19 Some processes are listed.  cytokinesis  differentiation  DNA replication  mitosis How many of the listed processes occur during tissue repair by stem cells? A 1 B 2 C 3 D 4

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2021

Q141 · The protein p53 is produced in a cell in response to DNA damage 9700/12 Feb/March 2022

20 The protein p53 is produced in a cell in response to DNA damage. This protein stops the cell cycle for a short time just before the DNA is replicated, so that the DNA can be repaired. At which phase of the cell cycle will this stop occur? A M B G1 C S D G2

1 marks

Answer: B

This question in 9700/12 Feb/March 2022

Q142 · Which processes require mitosis? 9700/11 May/June 2022

18 Which processes require mitosis? 1 the cloning of T-lymphocytes 2 the repair of cell structures by protein synthesis 3 the growth of multicellular organisms from a single cell 4 the reproduction of a unicellular eukaryote A 1, 2 and 3 B 1, 3 and 4 C 1 and 2 only D 3 and 4 only

1 marks

Answer: B

This question in 9700/11 May/June 2022

Q143 · Which events listed are part of the cell cycle? 9700/11 May/June 2022

19 Which events listed are part of the cell cycle? 1 interphase 2 prophase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/11 May/June 2022

Q144 · Telomerase is an enzyme that adds nucleotides to telomeres 9700/11 May/June 2022

20 Telomerase is an enzyme that adds nucleotides to telomeres. Which statement about telomerase is correct? A A high concentration of telomerase in a cell damages genes during DNA replication. B A high concentration of telomerase in cancerous cells limits the rate of tumour growth. C The low concentration of telomerase in stem cells means that these cells can divide an unlimited number of times. D The low concentration of telomerase in body cells means that these cells can divide a limited number of times.

1 marks

Answer: D

This question in 9700/11 May/June 2022

Q145 · What is a role of mitosis? 9700/12 May/June 2022

17 What is a role of mitosis? A growth of organisms B production of genetically different cells C repair of cells D replacement of cancerous tissue

1 marks

Answer: A

This question in 9700/12 May/June 2022

Q146 · Telomeres prevent the loss of genes from the ends of chromosomes during DNA replication… 9700/12 May/June 2022

18 Telomeres prevent the loss of genes from the ends of chromosomes during DNA replication, but they become shorter each time they are copied. In cancer cells and stem cells, the telomeres remain the same length. Which statement is correct for all human cells? A If telomeres become too short, a cell may stop dividing. B Adding telomeres could increase the rate of ageing of cells. C Telomeres are repaired by the enzyme RNA polymerase. D Telomeres prevent all damage occurring to DNA molecules.

1 marks

Answer: A

This question in 9700/12 May/June 2022

Q147 · The nucleus of a mouse body cell in G1 phase of the cell cycle has 1.2  10–12 g of DNA 9700/12 May/June 2022

19 The nucleus of a mouse body cell in G1 phase of the cell cycle has 1.2  10–12 g of DNA. What will be the mass of DNA in the nucleus of the cell at the end of S phase and at the end of G2 phase of the cell cycle? end of S phase end of G2 phase A 1.2  10–12 g 1.2  10–12 g B 1.2  10–12 g 2.4  10–12 g C 2.4  10–12 g 1.2  10–12 g D 2.4  10–12 g 2.4  10–12 g

1 marks

Answer: D

This question in 9700/12 May/June 2022

Q148 · Some cells are listed 9700/13 May/June 2022

18 Some cells are listed. 1 bacterial cells 2 cancer cells 3 lymphocytes 4 mature red blood cells 5 stem cells Which cells can divide by mitosis? A 1, 2, 4 and 5 B 1, 2 and 3 C 2, 3 and 5 D 3, 4 and 5

1 marks

Answer: C

This question in 9700/13 May/June 2022

Q149 · Which statement about telomeres is correct? 9700/13 May/June 2022

20 Which statement about telomeres is correct? A They allow cells in culture from any age of donor to divide a fixed number of times. B They are genes which are present on the 5 end of every chromosome. C They are unpaired regions of DNA on the 3 end of every chromosome. D They prevent introns and exons being lost from genes during cell division.

1 marks

Answer: D

This question in 9700/13 May/June 2022

Q150 · How many of these processes produce genetically identical cells? 9700/11 Oct/Nov 2022

18 How many of these processes produce genetically identical cells? ● growth of plant roots ● replacement of dead human skin cells ● repair of damaged muscle tissue ● asexual reproduction of coral A 1 B 2 C 3 D 4

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2022

Q151 · Which processes occur during interphase? 9700/11 Oct/Nov 2022

20 Which processes occur during interphase? 1 DNA replication 2 microtubule organisation 3 synthesis of ribosomes A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2022

Q152 · Embryonic stem cells are able to replicate continuously 9700/11 Oct/Nov 2022

21 Embryonic stem cells are able to replicate continuously. What happens to the telomeres during repeated mitotic cell cycles of embryonic stem cells? A Their lengths increase. B Their lengths decrease. C They are completely lost. D They stay the same length.

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2022

Q153 · The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles 9700/12 Oct/Nov 2022

18 The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells need to transcribe telomerase enzyme? 1 cancer cells 2 stem cells 3 activated memory B-lymphocytes A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/12 Oct/Nov 2022

Q154 · Which processes that occur in the cell cycle are represented in the diagram? 9700/12 Oct/Nov 2022

19 Which processes that occur in the cell cycle are represented in the diagram? 4 3 mass of nuclear DNA in a cell 2 / arbitrary units 1 0 time A DNA replication and nuclear division only B DNA replication, nuclear division and cytokinesis C mitosis and cytokinesis D mitosis only

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2022

Q155 · A gene codes for the production of a protein, p53, that binds to damaged DNA during… 9700/12 Oct/Nov 2022

20 A gene codes for the production of a protein, p53, that binds to damaged DNA during interphase and prevents its replication. A carcinogen in cigarette smoke mutates the gene coding for the p53 protein, preventing production of the protein. Which statement explains why this mutation may cause cancer? A Cells with no p53 are able to undergo mitosis. B Cells with no p53 replicate their damaged DNA. C The carcinogen in cigarette smoke increases the rate of cell division. D The mutated p53 causes uncontrolled cell division.

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2022

Q156 · The photomicrographs show cells in various stages of the cell cycle 9700/13 Oct/Nov 2022

19 The photomicrographs show cells in various stages of the cell cycle. In which stage does semi-conservative replication of DNA take place? A B C D

1 marks

Answer: C

This question in 9700/13 Oct/Nov 2022

Q157 · The diagram shows the epidermis of human skin 9700/13 Oct/Nov 2022

20 The diagram shows the epidermis of human skin. This is formed of four layers of cells. Cells in each layer have specific functions which are outlined on the diagram. As the cells are produced, they move upwards as shown by the arrow. cells in this layer are dead and eventually break away from the skin the keratinocyte cells continue to synthesise keratin and glycolipids to waterproof the skin the keratinocyte cells begin the synthesis of the protein keratin and a glycolipid that prevent water loss from the skin basal cells divide by mitosis and differentiate into the keratinocyte cells which move up into the layer above as they are produced Which row shows cells that are acting as stem cells in the skin epidermis and an organelle needed by the keratinocytes? cells that are acting organelle needed by as stem cells the keratinocytes A basal cells only centrioles B basal cells only Golgi body C basal cells and keratinocytes centrioles D basal cells and keratinocytes Golgi body

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2022

Q158 · The diagram shows some of the stages that take place during the cell cycle 9700/13 Oct/Nov 2022

21 The diagram shows some of the stages that take place during the cell cycle. 1 number of DNA molecules in cell doubles 4 stages 2 nuclear envelope during cell cell grows disappears cycle 3 chromosomes become visible Which two stages take place during interphase? A 1 and 2 B 1 and 3 C 2 and 4 D 3 and 4

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2022

Q159 · Which events are part of the mitotic cell cycle? 9700/12 Feb/March 2023

19 Which events are part of the mitotic cell cycle? 1 interphase 2 telophase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/12 Feb/March 2023

Q160 · The estimated total number of red blood cells in the human body is 2.5  1013 9700/12 Feb/March 2023

20 The estimated total number of red blood cells in the human body is 2.5  1013. It is estimated that, each day, 2.5  1011 red blood cells are removed from the circulation and are replaced by stem cells in the bone marrow. Which percentage of the total number of red blood cells is replaced each day? A 0.01% B 0.1% C 1% D 10%

1 marks

Answer: C

This question in 9700/12 Feb/March 2023

Q161 · The cell cycle includes mitosis 9700/11 May/June 2023

17 The cell cycle includes mitosis. What are features of this type of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically identical nuclei 3 semi-conservative replication of DNA A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only

1 marks

Answer: D

This question in 9700/11 May/June 2023

Q162 · How many copies of each DNA molecule will be found in a cell at the start of the stages… 9700/12 May/June 2023

21 How many copies of each DNA molecule will be found in a cell at the start of the stages of the mitotic cell cycle shown? G1 of cytokinesis interphase A 1 1 B 1 2 C 2 1 D 2 2

1 marks

Answer: B

This question in 9700/12 May/June 2023

Q163 · Which row describes some properties of stem cells? 9700/13 May/June 2023

21 Which row describes some properties of stem cells? able to divide by mitosis to produce more stem cells able to differentiate into specialised cells able to repair damaged cells 0 0O WwW D> ~*~ KKK v v x x Ke O&K key ¥ = is a property X = is not a property

1 marks

Answer: B

This question in 9700/13 May/June 2023

Q164 · The mitotic index is a measure of the proportion of cells that are undergoing mitosis in… 9700/13 May/June 2023

22 The mitotic index is a measure of the proportion of cells that are undergoing mitosis in an area of tissue. It is calculated using the formula shown. mitotic index = (number of cells undergoing mitosis ÷ total number of cells) × 100 A scientist calculated the mitotic index of areas of onion root at different distances from the tip of the root. The results are shown. 14 12 10 8 mitotic index 6 4 2 0 0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 distance from tip of root / mm Which statement is correct? A No cell division occurs further than 1.4 mm from the tip of the root. B The rate of cell division decreases as the distance from the root tip decreases. C Most of the cells undergoing cell division are closer to the tip of the root. D For a sample of 200 cells 0.2 mm from the tip of the root, 6 would be undergoing mitosis.

1 marks

Answer: C

This question in 9700/13 May/June 2023

Q165 · A human embryo consists of 12 cells at the start of day 1 9700/12 Oct/Nov 2023

18 A human embryo consists of 12 cells at the start of day 1. The cells divide by mitosis for 4 complete days at a rate of 1 division every 32 hours. What is the maximum number of cells in the embryo at the end of day 4? A 48 cells B 96 cells C 192 cells D 384 cells

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2023

Q166 · Which diagrams show roles of mitosis? 9700/12 Oct/Nov 2023

19 Which diagrams show roles of mitosis? 1 2 3 4 A 1, 2, 3 and 4 B 1, 2 and 3 only C 1 and 2 only D 3 and 4 only

1 marks

Answer: A

This question in 9700/12 Oct/Nov 2023

Q167 · Which events are part of the mitotic cell cycle? 9700/12 Oct/Nov 2023

20 Which events are part of the mitotic cell cycle? 1 interphase 2 anaphase 3 cytokinesis A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only

1 marks

Answer: A

This question in 9700/12 Oct/Nov 2023

Q168 · Which statements correctly describe features of stem cells that are essential for their… 9700/12 Feb/March 2024

22 Which statements correctly describe features of stem cells that are essential for their role in cell replacement and tissue repair? 1 After mitosis of stem cells, the daughter cells can either remain as stem cells or follow a developmental pathway that leads to the formation of specialised cells. 2 Stem cells are different to all other body cells because they retain all of the genetic information in their DNA throughout the life of the organism. 3 A small population of stem cells is retained in the body of adults throughout their life time. 4 Stem cells have more telomeres than other body cells and this allows them to undergo an unlimited number of mitotic divisions. A 1, 2, 3 and 4 B 1, 2 and 3 only C 1 and 3 only D 2, 3 and 4 only

1 marks

Answer: C

This question in 9700/12 Feb/March 2024

Q169 · Why is mitosis important in the immune response? 9700/11 May/June 2024

39 Why is mitosis important in the immune response? A It allows B-lymphocytes to produce plasma cells. B It allows B-lymphocytes to synthesise antibodies. C It allows neutrophils to carry out phagocytosis. D It allows T-lymphocytes to recognise foreign antigens.

1 marks

Answer: A

This question in 9700/11 May/June 2024

Q170 · Which metabolic processes will be very active in a cell that has just completed… 9700/12 May/June 2024

18 Which metabolic processes will be very active in a cell that has just completed cytokinesis? 1 ATP formation 2 DNA replication 3 protein synthesis A 1, 2 and 3 B 1 and 3 only C 2 only D 3 only

1 marks

Answer: B

This question in 9700/12 May/June 2024

Q171 · The diagram shows a typical mitotic cell cycle and the point in the cell cycle that has… 9700/12 May/June 2024

19 The diagram shows a typical mitotic cell cycle and the point in the cell cycle that has been reached by each of four cells, V, W, X and Y. mitosis cytokinesis Y X W G2 phase G1 phase S phase V Which row correctly identifies the cells that match the two descriptions? preparation for DNA replication is microtubule formation complete but the cell is nearly complete but has not yet reached chromosomes have its maximum size not yet condensed A V X B W Y C V Y D W X

1 marks

Answer: D

This question in 9700/12 May/June 2024

Q172 · The contents of a daughter cell are compared to the parent cell after one cell cycle 9700/13 May/June 2024

17 The contents of a daughter cell are compared to the parent cell after one cell cycle. Which row is correct? number of volume of length of chromosomes cytoplasm telomeres A increases remains the same decreases B increases decreases remains the same C remains the same remains the same remains the same D remains the same decreases decreases

1 marks

Answer: D

This question in 9700/13 May/June 2024

Q173 · Which statements about the cell cycle are correct? 9700/13 May/June 2024

19 Which statements about the cell cycle are correct? 1 The cell cycle includes interphase and mitosis. 2 DNA replication takes place in interphase. 3 A cell can remain in interphase for several months. A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/13 May/June 2024

Q174 · What are the correct roles of mitosis? 9700/11 Oct/Nov 2024

21 What are the correct roles of mitosis? stem cell growth replacing lost skin cells 00O WwW > x x LOK \ -« \ x& key ¥ = correct X = not correct

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2024

Q175 · Which row about the stages of the mitotic cell cycle is correct? 9700/11 Oct/Nov 2024

22 Which row about the stages of the mitotic cell cycle is correct? RNA polymerase DNA ligase used used in the in the nucleus nucleus A G1 phase S phase B G2 phase mitosis C mitosis G2 phase D S phase G1 phase

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2024

Q176 · Which processes occur in bone marrow cells that are in a mitotic cell cycle? 9700/12 Oct/Nov 2024

20 Which processes occur in bone marrow cells that are in a mitotic cell cycle? 1 Phosphate groups bind to ADP molecules to form ATP. 2 Bonds form between nucleotides in a DNA strand. 3 Hydrogen bonds form between tRNA anticodons and mRNA codons. A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only

1 marks

Answer: A

This question in 9700/12 Oct/Nov 2024

Q177 · The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles 9700/12 Oct/Nov 2024

21 The enzyme telomerase prevents loss of telomeres after many mitotic cell cycles. Which cells need to transcribe telomerase enzyme? 1 stem cells 2 activated memory B-lymphocytes 3 helper T-lymphocytes secreting cytokines A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2024

Q178 · Which process does not involve mitosis? 9700/13 Oct/Nov 2024

18 Which process does not involve mitosis? A asexual reproduction B growth of unicellular organisms C repair of tissues by cell replacement D replacement of damaged or dead cells

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2024

Q179 · The diagram shows an outline of the mitotic cell cycle 9700/13 Oct/Nov 2024

20 The diagram shows an outline of the mitotic cell cycle. 1 2 cytokinesis 3 Which numbered stages of the cell cycle include a period of time when each chromosome consists of sister chromatids joined by a centromere? A 1 and 2 B 1 and 3 C 2 and 3 D 2 only

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2024

Q180 · A nucleus in a body cell of a species of fruit fly has 8 chromosomes 9700/12 Feb/March 2025

19 A nucleus in a body cell of a species of fruit fly has 8 chromosomes. How many strands of DNA are present in the nucleus at the end of interphase? A 8 B 16 C 32 D 64

1 marks

Answer: C

This question in 9700/12 Feb/March 2025

Q181 · The statements are about two genes and their protein products that can have a role in… 9700/12 Feb/March 2025

22 The statements are about two genes and their protein products that can have a role in tumour formation. ● The protein coded for by the PTEN gene prevents cells from growing and dividing too rapidly. ● The protein coded for by the p53 gene prevents cells progressing through the mitotic cell cycle if the cells have damaged DNA. Which combination of mutations of these two genes in an individual is most likely to result in the formation of a tumour? gene PTEN p53 A mutation present mutation present B no mutation mutation present C mutation present no mutation D no mutation no mutation

1 marks

Answer: A

This question in 9700/12 Feb/March 2025

Q182 · Telomerase is an enzyme that prevents the shortening of telomeres 9700/12 Feb/March 2025

23 Telomerase is an enzyme that prevents the shortening of telomeres. It is not present in most normal cells, but is active in an estimated 85% to 95% of human tumour cells. Which statement explains the effect of telomerase on human tumour cells? A Telomerase triggers a self-destruct process, known as apoptosis, ending the life of the cell. B Telomerase damages the chromosomes so they become genetically unstable and are unable to replicate and divide. C Telomerase helps human tumour cells avoid senescence, or cell death, which is usually the expected consequence of repeated cell division. D Telomerase enables the human tumour cells to divide more rapidly by reducing the time taken for a complete mitotic cell cycle.

1 marks

Answer: C

This question in 9700/12 Feb/March 2025

Q183 · During which phase of the cell cycle does DNA replication take place? 9700/12 May/June 2025

22 During which phase of the cell cycle does DNA replication take place? A G1 B G2 C M D S

1 marks

Answer: D

This question in 9700/12 May/June 2025

Q184 · The epithelium that lines the stomach is damaged by acid and is renewed every two days 9700/14 May/June 2025

21 The epithelium that lines the stomach is damaged by acid and is renewed every two days. Why is mitosis required to repair the damage? A Mitosis repairs damaged cells. B Mitosis produces new genetically similar cells. C Mitosis provides genetically identical replacement cells. D Mitosis doubles the original cell number.

1 marks

Answer: C

This question in 9700/14 May/June 2025

Q185 · Telomeres become shorter during each cell cycle of a specialised cell 9700/11 Oct/Nov 2025

20 Telomeres become shorter during each cell cycle of a specialised cell. In which phase of the cell cycle do telomeres shorten? A cytokinesis B G1 C S D G2

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2025

Q186 · What are roles of adult stem cells in humans? 9700/13 Oct/Nov 2025

21 What are roles of adult stem cells in humans? 1 repair other cells by mitosis 2 divide to replace cells in tissues 3 differentiate into a new organism A 1 and 3 B 1 only C 2 and 3 D 2 only

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2025

Q187 · Which statements are correct for the mitotic cell cycle? 9700/13 Oct/Nov 2025

22 Which statements are correct for the mitotic cell cycle? 1 DNA is replicated semi-conservatively during mitosis. 2 DNA is never changed from one generation of cells to the next generation. 3 The daughter cells at the end of a mitotic cell division have the potential to produce the same enzymes as the parent cell. 4 The same quantity of DNA is distributed to the nuclei of two new cells at the end of a mitotic cell division. A 1 and 2 B 1 and 4 C 2 and 3 D 3 and 4

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2025