Chromosome behaviour in mitosis — Paper 1 · A Level Biology 9700

19 The graph shows measurements taken during one mitotic cell cycle. X 2 distance 1 0 5 10 15 20 25 time / minutes Which stage of mitosis begins at X and which measurements are shown by curves 1 and 2? distance between distance between stage centromeres of centromeres of beginning at X chromosomes and sister chromatids poles of spindle A anaphase 1 2 B anaphase 2 1 C metaphase 1 2 D metaphase 2 1

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2004

21 Which process occurs during prophase of mitosis in an animal cell? A division of centromeres B formation of chromosomes C replication of DNA D separation of centrioles

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2004

19 What are the conditions in a human cell just before the cell enters prophase? number of number of molecules nuclear envelope spindle present chromatids of DNA in nucleus present A 46 46 yes no B 92 46 no yes C 46 92 yes yes D 92 92 no yes

1 marks

Answer: D

This question in 9700/11 May/June 2006

18 The diagram shows the chromosomes of a cell at late prophase of mitosis. What will be the appearance of the products of this cell division as they enter prophase of their next division? A B C D

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2006

19 Each of the following events takes place during mitosis. 1 centromeres divide 2 chromatids move to opposite poles of the cell 3 chromosomes line up along the equator of the spindle 4 chromosomes uncoil 5 two chromatids are joined by a centromere In which order do the events take place? first last A 1 2 4 5 3 B 3 1 2 4 5 C 4 5 3 1 2 D 5 3 1 2 4

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2007

19 The diagram shows a cell of an organism formed by reduction division. What is the diploid number for this organism? A 10 B 20 C 40 D 46

1 marks

Answer: C

This question in 9700/11 May/June 2008

20 The graph shows three measurements obtained following metaphase of mitosis. 60 50 3 40 distance / µm 30 2 1 20 10 0 0 5 10 15 20 25 30 time / minutes What measurements do the curves represent? distance between distance between distance between centromeres and centromeres of sister poles of spindle poles of spindle chromatids A 1 2 3 B 1 3 2 C 3 1 2 D 3 2 1

1 marks

Answer: A

This question in 9700/11 May/June 2008

19 What is a correct description of the centrioles, nuclear envelope and spindle during mitosis in animal cells? phase centrioles nuclear envelope spindle A anaphase replicate absent present B metaphase present reforms present C prophase move apart breaks up forms D telophase replicate breaks up breaks up

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2008

19 What occurs in anaphase of mitosis? A chromatids line up on the equator of the cell B chromatids reach the poles of the spindle C chromatids separate and move to opposite poles D chromatids start to coil up and become visible

1 marks

Answer: C

This question in 9700/11 May/June 2010

20 The diagram shows chromosomes at metaphase of mitosis. What are the diploid and haploid numbers for this species? diploid haploid A 4 8 B 8 4 C 8 16 D 16 8

1 marks

Answer: B

This question in 9700/11 May/June 2010

19 The diagram shows chromosomes at metaphase of mitosis. What are the diploid and haploid numbers for this species? diploid haploid A 4 8 B 8 4 C 8 16 D 16 8

1 marks

Answer: B

This question in 9700/12 May/June 2010

21 What occurs in anaphase of mitosis? A chromatids line up on the equator of the cell B chromatids reach the poles of the spindle C chromatids separate and move to opposite poles D chromatids start to coil up and become visible

1 marks

Answer: C

This question in 9700/12 May/June 2010

26 What occurs in anaphase of mitosis? A chromatids line up on the equator of the cell B chromatids reach the poles of the spindle C chromatids separate and move to opposite poles D chromatids start to coil up and become visible

1 marks

Answer: C

This question in 9700/13 May/June 2010

27 The diagram shows chromosomes at metaphase of mitosis. What are the diploid and haploid numbers for this species? diploid haploid A 4 8 B 8 4 C 8 16 D 16 8

1 marks

Answer: B

This question in 9700/13 May/June 2010

18 Male bees are haploid. They develop from unfertilised eggs. Female bees are diploid. Which statements are correct? 1 All male bees are genetically identical. 2 Male bee sperm cells are produced by mitosis. 3 New combinations of genes only occur in female bees. A 1 and 2 only B 1 and 3 only C 2 and 3 only D 1, 2 and 3

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2010

16 The cell cycle includes mitosis. Which are features of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically identical cells 3 semi-conservative replication of DNA A 2 only B 1 and 2 only C 2 and 3 only D 1, 2 and 3

1 marks

Answer: A

This question in 9700/12 Oct/Nov 2010

18 The diagram shows the chromosomes of a typical plant cell at the metaphase stage of mitosis. “xX : a D4 Which row describes this cell during metaphase? diploid number (2n) | structures present at metaphase for the plant cell wall centriole spindle A 4 v x v B 8 x v v Cc 8 v x v D 16 v v x

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2010

19 Which process occurs during prophase of the mitotic cell cycle in an animal cell? A division of centromeres B formation of chromosomes C replication of DNA D separation of centrioles

1 marks

Answer: D

This question in 9700/11 May/June 2011

19 At which stage of mitosis do these events occur? spiralisation and centromeres separate condensation of DNA A anaphase interphase B anaphase prophase C metaphase interphase D metaphase telophase

1 marks

Answer: B

This question in 9700/12 May/June 2011

26 Which process occurs during prophase of the mitotic cell cycle in an animal cell? A division of centromeres B formation of chromosomes C replication of DNA D separation of centrioles

1 marks

Answer: D

This question in 9700/13 May/June 2011

28 Meiosis and mitosis are two types of cell division. A cell has 10 chromosomes before it divides. How many chromosomes will it have after dividing by meiosis or mitosis? meiosis mitosis A 5 10 B 5 20 C 10 5 D 20 5

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2011

18 What occurs during metaphase of mitosis? A chromosomes attach to the equator of the spindle B chromosomes become shorter and thicker C chromatids reach the poles of the spindle D each chromosome forms two chromatids

1 marks

Answer: A

This question in 9700/11 May/June 2012

17 Each of the following events takes place during mitosis. 1 centromeres divide 2 chromatids move to opposite poles of the cell 3 chromosomes line up along the equator of the spindle 4 chromosomes uncoil 5 two chromatids are joined by a centromere In which order do the events take place? first last A 1 2 4 5 3 B 3 1 2 4 5 C 4 5 3 1 2 D 5 3 1 2 4

1 marks

Answer: D

This question in 9700/12 May/June 2012

21 What occurs during metaphase of mitosis? A chromosomes attach to the equator of the spindle B chromosomes become shorter and thicker C chromatids reach the poles of the spindle D each chromosome forms two chromatids

1 marks

Answer: A

This question in 9700/13 May/June 2012

19 The diagram shows the chromosomes of one cell which has been squashed during mitosis. Which stage of mitosis is shown and what is the haploid chromosome number in this species? haploid chromosome stage of mitosis number A anaphase 5 B anaphase 10 C metaphase 5 D metaphase 10

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2012

20 The diagram shows a cell of an organism formed by reduction division. What is the diploid number for this organism? A 10 B 20 C 40 D 46

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2012

17 Which diagram represents a cell undergoing metaphase of mitosis? A B C D

1 marks

Answer: C

This question in 9700/13 Oct/Nov 2012

21 Nocodazole is a chemical used in the study of mitosis. It causes all mitotic cells to stop dividing at metaphase. Which statements correctly identify how this chemical might work? 1 inhibits chromatin condensing in the nucleus 2 prevents replication of the centrioles 3 stops sister chromatids migrating to opposite poles A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 3 only

1 marks

Answer: D

This question in 9700/11 May/June 2013

20 The diagram shows a cell nucleus in prophase of mitosis. Which statement describes the chromosomes found in each daughter nucleus immediately following division of this cell by mitosis? A 8 chromosomes, each consisting of 4 chromatids B 8 chromosomes, each containing 1 molecule of DNA C 4 chromosomes, each consisting of 4 chromatids D 16 chromosomes, each containing 1 molecule of DNA

1 marks

Answer: B

This question in 9700/12 May/June 2013

21 Which features of mitosis ensure that the genetic constitution of the cell is maintained? 1 the position of the chromosomes on the equator of the spindle 2 the longitudinal division of the centromeres 3 the DNA of the parent cells replicates before mitosis begins 4 the pulling apart of the chromatids to opposite poles A 1, 2 and 3 only B 1, 2 and 4 only C 2, 3 and 4 only D 1, 2, 3 and 4

1 marks

Answer: C

This question in 9700/12 May/June 2013

20 The diagram shows a cell nucleus in prophase of mitosis. Which statement describes the chromosomes found in each daughter nucleus immediately following division of this cell by mitosis? A 2 chromosomes, each consisting of 2 chromatids B 4 chromosomes, each consisting of 2 chromatids C 8 chromosomes, each containing 1 molecule of DNA D 4 chromosomes, each containing 1 molecule of DNA

1 marks

Answer: D

This question in 9700/13 May/June 2013

18 The diagram shows an outline of the process of sexual reproduction. adult cell adult cell 1 1 gamete P gamete fertilisation Q zygote 2 fetus Which row identifies the type of cell division occurring during stages 1 and 2 and the number of chromosomes in cells P and Q? 1 2 P Q A meiosis meiosis diploid haploid B meiosis mitosis haploid diploid C mitosis meiosis haploid diploid D mitosis mitosis diploid haploid

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2013

18 The graph shows the change in the quantity of DNA in a cell during a reduction division (meiosis). 4 quantity of DNA / arbitrary units 2 0 time A cell with one pair of chromosomes (2n = 2) undergoes meiosis. Which nucleus is formed as a result of this division? A B C D

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2013

20 The diagram shows a human cell (2n = 46) at the end of prophase of mitosis (cell 1) and the daughter cells just after telophase (cells 2 and 3). cell 1 cell 2 cell 3 How many DNA molecules are there in the nucleus of cell 1 and cell 2? cell 1 cell 2 A 46 23 B 46 46 C 92 23 D 92 46

1 marks

Answer: D

This question in 9700/11 May/June 2014

17 The cell cycle includes mitosis. Which are features of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically identical cells 3 semi-conservative replication of DNA A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only

1 marks

Answer: D

This question in 9700/12 May/June 2014

19 Diploid (2n) organisms that reproduce sexually produce haploid (n) gametes. Some plants, such as wheat, can produce diploid or haploid gametes. These gametes can fertilise other diploid or haploid gametes. Which statements are correct for plants like these? 1 Diploid gametes may be produced by a fault in the reduction division (meiosis). 2 The offspring will always show an increased chromosome number. 3 The offspring could be either 2n, 3n or 4n. 4 The chromosome number could, in theory, increase with each generation. A 1, 2 and 3 B 1, 2 and 4 C 1, 3 and 4 D 2, 3 and 4

1 marks

Answer: C

This question in 9700/12 May/June 2014

20 The photomicrograph shows cells in different stages of mitosis. 1 5 2 4 3 In which order do these stages occur? A 3 → 5 → 2 → 1 → 4 B 3 → 5 → 1 → 2 → 4 C 4 → 3 → 5 → 1 → 2 D 4 → 5 → 1 → 2 → 3

1 marks

Answer: B

This question in 9700/13 May/June 2014

19 A student examined the cells in the growing region (meristem) of an onion root and obtained the data below. stage number of cells interphase 886 prophase 73 metaphase 16 anaphase 14 telophase 11 What percentage of cells contain chromosomes that appear as two chromatids? A 97.5 % B 95.9 % C 8.9 % D 7.3 %

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2014

18 The graphs show various measurements taken from metaphase of mitosis onwards. The graphs are to scale when compared to one another. X distance time Y distance time Z distance time Which row correctly identifies each graph? X Y Z A distance between poles distance between distance of centromere of spindle sister chromatids from pole of spindle B distance between poles distance of centromere distance between of spindle from pole of spindle sister chromatids C distance of centromere distance between distance between from pole of spindle poles of spindle sister chromatids D distance of centromere distance between distance between poles from pole of spindle sister chromatids of spindle

1 marks

Answer: C

This question in 9700/11 May/June 2015

19 Which row is correct? diagram stage A interphase B metaphase C telophase D anaphase

1 marks

Answer: D

This question in 9700/12 May/June 2015

18 The diagrams show chromosomes at different stages of mitosis. W X Y Z Which shows the correct order of the cell cycle? A W → X → Y → Z B X → Y → Z → W C Y → Z → W → X D Z → W → X → Y

1 marks

Answer: B

This question in 9700/13 May/June 2015

18 The photomicrograph shows a cell during mitosis. What is happening in this cell? 1 Centrioles are replicating. 2 Spindle microtubules are shortening. 3 Chromatin is condensing. A 1, 2 and 3 B 1 and 2 only C 2 only D 3 only

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2015

18 Which statements about a diploid cell are correct? 1 can divide by mitosis to repair itself 2 has two complete sets of chromosomes 3 can undergo a reduction division to form haploid cells 4 can undergo mitotic division to allow growth to occur A 1, 2 and 3 B 1, 2 and 4 C 1, 3 and 4 D 2, 3 and 4

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2015

18 The photomicrograph shows a cell undergoing mitosis. What is happening in this cell? A Centrioles are replicating. B Chromatin is condensing. C DNA is replicating. D Spindle microtubules are shortening.

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2015

17 The diagram shows cells in different stages of the cell cycle. Which is the last stage before cytokinesis? A B C D

1 marks

Answer: C

This question in 9700/12 Feb/March 2016

17 Which processes occur during prophase of the mitotic cell cycle in an animal cell? centrioles chromosomes | spindle fibres replicate condense form v v x key ¥ = true 0 0O WwW D> Jv x x x Jv Jv X = false x x Jv

1 marks

Answer: C

This question in 9700/11 May/June 2016

16 The photomicrographs show cells in various stages of the cell cycle. 1 2 3 4 Which cells contain twice as many DNA molecules as a cell from the same organism after cytokinesis? A 1, 2, 3 and 4 B 1, 2 and 4 only C 1 and 3 only D 2 and 4 only

1 marks

Answer: A

This question in 9700/12 May/June 2016

17 A group of chemicals used to treat cancer prevents the formation of the spindle during mitosis. Which phase of mitosis is the first to be affected? A anaphase B metaphase C prophase D telophase

1 marks

Answer: C

This question in 9700/12 May/June 2016

17 Which process occurs during prophase of the mitotic cell cycle in an animal cell? A division of centromeres B formation of chromosomes C replication of DNA D separation of centrioles

1 marks

This question in 9700/13 May/June 2016

17 Which row is correct for a human cell just before the cell enters prophase of mitosis? number of number of molecules nuclear envelope spindle present chromatids of DNA in nucleus present A 46 46 yes no B 46 92 yes yes C 92 46 no yes D 92 92 no yes

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2016

19 The information describes some events of mitosis. 1 chromosomes undergo condensation and spiralisation 2 centromeres are pulled by shortening of spindle fibres 3 sister chromatids are orientated across the centre of the cell 4 centrioles separate from each other 5 spindle fibres disperse Which row correctly identifies the stages of mitosis in which these events occur? 1 2 3 4 5 A metaphase telophase prophase metaphase anaphase B prophase anaphase metaphase prophase telophase C prophase metaphase anaphase telophase telophase D telophase metaphase prophase anaphase prophase

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2016

23 The statements describe events during the mitotic cell cycle. 1 Chromosomes migrate to opposite poles of the spindle. 2 Chromosomes arrange themselves at the equator of the spindle. 3 Chromosomes condense and the nuclear membrane disappears. 4 Centromeres divide. What is the correct order of three of these events in the mitotic cell cycle? A 2 → 3 → 4 B 3 → 2 → 4 C 3 → 4 → 2 D 4 → 2 → 1

1 marks

Answer: B

This question in 9700/12 Feb/March 2017

22 The electron micrograph shows a group of human chromosomes. W Y X Which label is correct for each of the structures labelled W, X and Y? W X Y A centriole centromere chromatid B centriole centromere microtubule C centromere telomere chromatid D centromere telomere microtubule

1 marks

Answer: C

This question in 9700/11 May/June 2017

23 Which statement about the behaviour of chromosomes during mitosis is correct? A They attach to the spindle fibres to contain them within the nucleus. B They condense to prevent further translation of genes. C They reach the poles of the cell and become longer and thinner. D They replicate to produce sufficient DNA to form two new nuclei.

1 marks

Answer: C

This question in 9700/11 May/June 2017

16 The photomicrograph shows a stage of mitosis. What would be correct for the next stage in mitosis? paired chromatids nuclear membrane A absent absent B absent re-forming C present absent D present breaking down

1 marks

Answer: A

This question in 9700/12 May/June 2017

17 The diagram shows part of the organisation of a DNA molecule and the associated histones. P Q R Which statement about the features labelled P, Q and R during prophase of mitosis is correct? A The coiled DNA molecule forms Q and wraps around the histones of R to form small clusters held in place by histone P. B The groups of histones, P, and its associated DNA, Q, move closer together as the chromosome condenses around R. C The histones P and R are made of protein around which the DNA molecule, Q, is wrapped so that the DNA molecule can fit inside the nucleus. D The linked groups of histones P and R and the associated DNA, Q, form strands that fold and twist together to form a chromatid.

1 marks

Answer: D

This question in 9700/12 May/June 2017

17 The photomicrograph shows cells undergoing mitosis. X Which statement describes what will happen next in cell X? A Chromatin coils up tightly, and the nuclear envelope breaks down. B Chromosomes line up along the equator of the cell and attach to the spindle. C Sister chromatids move towards opposite poles, pulled by the spindle fibres. D Spindle fibres break down, and the cell prepares for cytokinesis.

1 marks

Answer: B

This question in 9700/13 May/June 2017

20 The diagram shows the structure of one chromosome. 1 2 Which row is correct? number of 1 2 DNA strands A centromere chromatid 2 B centromere telomere 4 C chromatid telomere 2 D telomere chromatid 4

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2017

20 What describes a telomere? A a cell structure composed mainly of protein and involved in cell division B a protein that associates with DNA to help condense it C a region of DNA that links two sister chromatids together D a region of repetitive nucleotide sequences at the end of a chromatid

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2017

21 Three parts of a chromosome and their functions are listed. part P1 centromere P2 histone proteins P3 telomere function F1 packages DNA into compact structures F2 holds two chromatids together F3 prevents loss of genes Which combination is correct? A P1 and F1 B P1 and F3 C P2 and F2 D P3 and F3

1 marks

Answer: D

This question in 9700/12 Feb/March 2018

22 The graphs show various distance measurements taken from metaphase of mitosis onwards. The graphs are to scale when compared to one another. X distance time Y distance time Z distance time Which row correctly identifies the distance measurement for each graph? X Y Z A distance between distance between distance of centromeres poles of spindle sister chromatids from poles of spindle B distance between distance of centromeres distance between poles of spindle from poles of spindle sister chromatids C distance of centromeres distance between distance between from poles of spindle poles of spindle sister chromatids D distance of centromeres distance between distance between from poles of spindle sister chromatids poles of spindle

1 marks

Answer: C

This question in 9700/12 Feb/March 2018

18 A student observed the cells in the growing region (meristem) of an onion root and obtained the data shown. stage number of cells interphase 886 prophase 73 metaphase 16 anaphase 14 telophase 11 Which percentage of cells contains chromosomes that appear as two chromatids? A 7.3 B 8.9 C 95.9 D 97.5

1 marks

Answer: B

This question in 9700/11 May/June 2018

19 The chromosome content of each daughter cell must be identical to that of the mother cell for successful cell replacement when repairing tissues. Which stages of mitosis make sure that each daughter cell receives one chromatid from each chromatid pair? A prophase and metaphase B metaphase and anaphase C anaphase and telophase D telophase and interphase

1 marks

Answer: B

This question in 9700/12 May/June 2018

21 Which statement is correct about the number of telomeres present in prophase of a human body cell? A 46 as there is one telomere at the end of 46 chromosomes B 92 as there is one telomere at each end of 46 chromosomes C 92 as there is one telomere at the end of 92 chromatids D 184 as there is one telomere at each end of 92 chromatids

1 marks

Answer: D

This question in 9700/12 May/June 2018

20 Which row shows the appearance of a chromosome at the beginning of prophase of mitosis and the number of DNA strands in the chromosome? appearance of number of one chromosome DNA strands A 2 B 4 C 1 D 2

1 marks

Answer: B

This question in 9700/13 May/June 2018

21 The graph shows measurements taken during one mitotic cell cycle. X 2 1 distance 0 5 10 15 20 25 time / minutes Which stage of mitosis begins at X and which measurements are shown by curves 1 and 2? distance between distance between stage centromeres of centromeres of beginning at X chromosomes and sister chromatids poles of spindle A anaphase 1 2 B anaphase 2 1 C metaphase 1 2 D metaphase 2 1

1 marks

Answer: A

This question in 9700/13 May/June 2018

20 The photomicrograph shows cells in different stages of mitosis. P T Q S R Which statements are correct? 1 Cell T shows metaphase. 2 DNA replication occurs in cell R. 3 The amount of DNA in cell P is the same as in cell T. 4 The correct order for the stages is S → R → T → P → Q. A 1, 2 and 3 B 1, 2 and 4 C 1, 3 and 4 D 2, 3 and 4

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2018

22 Which row shows some of the events during a mitotic cycle in the correct time sequence? time A centromere of nucleoli become nuclear envelope spindle each chromosome visible breaks into small microtubules splits vesicles produced B nuclear envelope spindle centromere of nucleoli become breaks into small microtubules each chromosome visible vesicles produced splits C nucleoli become nuclear envelope spindle centromere of visible breaks into small microtubules each chromosome vesicles produced splits D spindle centromere of nucleoli become nuclear envelope microtubules each chromosome visible breaks into small produced splits vesicles

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2018

21 Centromere, chromatids and telomeres are parts of a chromosome in a eukaryotic cell. Which row correctly describes these structures? centromere chromatid telomere A binds the two sister contains histone proteins protects the tips of each chromatids of a and a molecule of chromatid from shortening at chromosome together double-stranded DNA each mitotic division B site of attachment of contains histone proteins prevents the genes nearest spindle microtubules and a molecule of the ends of each chromatid single-stranded DNA from being lost C site of production of contains a molecule of contains DNA with many spindle microtubules double-stranded DNA with no repeats of short base associated histone proteins sequences D splits at metaphase contains a molecule of ensures that when DNA is of mitosis single-stranded DNA with no replicated, the ends of the associated histone proteins molecule are included

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2018

19 During mitosis in animal cells, which process occurs after prophase? A Centrioles move towards the poles of the cell. B Centromeres attach to spindle microtubules. C Chromatids join to form chromosomes. D Chromosomes condense and become visible.

1 marks

Answer: B

This question in 9700/12 Feb/March 2019

18 A scientist stains the chromosomes of a diploid plant cell with a fluorescent dye to observe the telomeres. This cell has 38 chromosomes. How many telomeres will the scientist observe in one of the nuclei during telophase of mitosis? A 38 B 76 C 114 D 152

1 marks

Answer: B

This question in 9700/11 May/June 2019

19 The photomicrograph shows a cell during mitosis. What is happening in this cell? 1 Centrioles are replicating. 2 Spindle microtubules are shortening. 3 Chromatin is condensing. A 1, 2 and 3 B 1 and 2 only C 2 only D 3 only

1 marks

Answer: C

This question in 9700/11 May/June 2019

21 The graph shows the length of the spindle fibres during mitosis. Which region of the graph shows when all the centromeres have detached from the spindle fibres? B C length of spindle fibres A D time

1 marks

Answer: D

This question in 9700/11 May/June 2019

15 Three parts of a chromosome and their functions are listed. part function P1 centromere F1 holds the coils of DNA together P2 histone proteins F2 holds two chromatids together P3 telomere F3 prevents loss of genes Which part is matched with its correct function? A P1 and F1 B P2 and F1 C P2 and F3 D P3 and F2

1 marks

Answer: B

This question in 9700/12 May/June 2019

21 Some parts of a typical human chromosome are more numerous than others. Which of the parts are listed in order from the most numerous to the least numerous? A centromere, nucleotide, histone B DNA molecule, telomere, centromere C histone, telomere, DNA molecule D telomere, centromere, nucleotide

1 marks

Answer: C

This question in 9700/13 May/June 2019

23 The diagram shows a cell during mitosis. Which description correctly identifies the cell? A a plant cell during anaphase B a plant cell during metaphase C an animal cell during anaphase D an animal cell during metaphase

1 marks

Answer: C

This question in 9700/13 May/June 2019

20 At which stage of mitosis do these events occur? chromosomes become centromeres separate shorter and thicker A anaphase interphase B anaphase prophase C metaphase interphase D metaphase prophase

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2019

20 Which row shows the correct number of each component of a single chromosome during prophase of mitosis? polynucleotide centromeres chromatids telomeres strands A 1 0 2 2 B 1 2 4 4 C 2 0 4 2 D 2 2 2 4

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2019

19 The graph shows three measurements obtained after metaphase of mitosis. 3 2 distance 1 time What measurements do the curves represent? distance between distance between distance between centromeres and centromeres of sister poles of spindle poles of spindle chromatids A 1 2 3 B 1 3 2 C 3 1 2 D 3 2 1

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2019

21 Which row shows part of the correct sequence of mitosis? A chromosomes nuclear chromosomes spindle fibres → line up at the → envelope → condense shorten equator disappears B chromosomes nuclear spindle fibres chromosomes line up at the → → → envelope shorten condense equator reappears C chromosomes nuclear spindle fibres chromosomes line up at the → → envelope → shorten uncoil equator reappears D nuclear chromosomes chromosomes spindle fibres → envelope → → line up at the uncoil shorten disappears equator

1 marks

Answer: C

This question in 9700/12 Feb/March 2020

18 During prophase, a scientist stains the chromosomes of a diploid animal cell with a fluorescent dye to stain telomeres. This cell has 32 chromosomes. How many telomeres will the scientist observe? A 32 B 64 C 96 D 128

1 marks

Answer: D

This question in 9700/11 May/June 2020

19 Which description of chromosome structure is correct? A A chromosome at the beginning of interphase consists of two identical chromatids, each containing one linear molecule of DNA. B Telomeres are lengths of non-coding DNA found at one end of each chromatid to prevent loss of genes during cell division. C The two identical chromatids of a chromosome are held together by a centromere in which there is no DNA. D The very long DNA molecule of each chromatid is coiled and held together by proteins called histones.

1 marks

Answer: D

This question in 9700/12 May/June 2020

21 A drug has been developed to treat certain types of cancer. It prevents mitosis by binding to the spindle and preventing sister chromatids being separated and moving to opposite poles of the cell. The photomicrograph shows cells in different phases of mitosis. 1 2 3 4 What represents the stages of mitosis that will be able to occur in a cell which is entering prophase when treated with this drug? A 1 and 2 B 2 and 3 C 2 only D 3 and 4

1 marks

Answer: A

This question in 9700/12 May/June 2020

17 Which row correctly describes parts of chromosome structure present during mitosis? centromere chromatid telomere A region of a single DNA region of DNA with chromosome polynucleotide with many cytosine and with no DNA histone proteins guanine bases B region of non-coding DNA double-stranded region of DNA with holding two DNA molecule with many short repeated chromatids together histone proteins sequences of bases C region of DNA with no DNA molecule coiled region of DNA with no histone proteins that allows round histone proteins proteins that protects separation of chromatids to form a chain of the end of a chromatid during anaphase nucleosomes D region that attaches one of two identical region of non-coding to spindle microtubules DNA molecules that DNA holding the and divides was replicated ends of the during prophase during interphase chromatids together

1 marks

Answer: B

This question in 9700/13 May/June 2020

18 During telophase of mitosis, a scientist stains the chromosomes of a diploid animal cell with a fluorescent dye to observe the telomeres. This cell has 22 chromosomes. How many telomeres will the scientist observe in one of the nuclei? A 22 B 44 C 66 D 88

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2020

20 Which stage of mitosis is correctly described? A In anaphase chromosomes line up across the equator. B In metaphase the centrosomes replicate. C In prophase chromatids move to opposite poles. D In telophase chromosomes uncoil to form chromatin.

1 marks

Answer: D

This question in 9700/11 Oct/Nov 2020

19 Three parts of a chromosome and their functions are listed. part function p1 centromere f1 holds the coils of DNA together p2 histone proteins f2 holds two chromatids together p3 telomere f3 prevents loss of genes Which part is matched with its correct function? A p1 and f2 B p2 and f2 C p2 and f3 D p3 and f1

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2020

18 DNA molecules in a eukaryotic cell must be packaged compactly because their combined length is much greater than the diameter of the nucleus. Which structures are required during the process of packaging DNA molecules compactly? A chromatids B chromosomes C histone proteins D telomeres

1 marks

Answer: C

This question in 9700/12 Feb/March 2021

20 A human chromosome is made up of different parts. Some parts of a typical human chromosome are more numerous than others. Which parts are listed in order from least numerous to most numerous in a human white blood cell? A centromere  chromatid  histone protein B DNA molecule  telomere  centromere C histone protein  telomere  DNA molecule D telomere  centromere  chromatid

1 marks

Answer: A

This question in 9700/12 Feb/March 2021

17 At which stages of mitosis are chromosomes composed of two chromatids that are held together by a centromere? A anaphase and telophase B anaphase and prophase C metaphase and prophase D metaphase and telophase

1 marks

Answer: C

This question in 9700/11 May/June 2021

17 Human chromosomes have different parts. Some parts are more numerous than others. Which parts are listed in order from most numerous to least numerous in a human white blood cell? A centromere  nucleotide  histone protein B DNA molecule  telomere  centromere C histone protein  telomere  DNA molecule D telomere  centromere  nucleotide

1 marks

Answer: C

This question in 9700/12 May/June 2021

20 The graph shows how the distance between sister chromatids (curve P) and the distance between chromatids and centrioles (curve Q) changes during part of mitosis. 40 curve P distance / μm 20 curve Q 0 T V W X time Which statements could be correct? 1 T to V represents interphase. 2 T to W represents metaphase. 3 W to X represents anaphase. A 1 and 3 B 2 and 3 C 1 only D 2 only

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2021

18 Which description is correct? A A centromere holds two chromatids together until the end of prophase and attaches to the microtubules of the spindle. B A chromatid is one of two identical parts of a chromosome and is made of proteins and two molecules of DNA. C A chromosome is a structure with two identical parts, made of DNA and proteins, found in the nucleus of a prokaryotic cell. D A telomere is a sequence of DNA nucleotides, such as GGGTAA, repeated many times and found at the ends of each chromatid.

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2021

19 During metaphase, a scientist stains the chromosomes of a diploid animal cell with fluorescent dye to allow the telomeres to be observed. This cell has 26 chromosomes. How many telomeres will the scientist observe? A 26 B 52 C 78 D 104

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2021

18 Which row shows the correct number of each component of a single chromatid during anaphase of mitosis? polynucleotide centromeres telomeres strands A 1 2 2 B 1 4 4 C 2 2 4 D 2 4 2

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2021

20 The photomicrographs show cells in various stages of the cell cycle. Which stage of mitosis is not shown? A anaphase B prophase C metaphase D telophase

1 marks

Answer: C

This question in 9700/13 Oct/Nov 2021

21 Some parts of a typical human chromosome are more numerous than others. Which parts are listed in order from the most numerous to the least numerous? A centromere, nucleotide, histone B DNA molecule, telomere, centromere C histone, telomere, DNA molecule D telomere, centromere, nucleotide

1 marks

Answer: C

This question in 9700/12 Feb/March 2022

22 Which row correctly describes a stage of mitosis? stage of mitosis nuclear envelope centromeres spindle A prophase disappears replicate spindle microtubules begin to form B metaphase not present move to the spindle microtubules poles of the cell fully formed C anaphase begins to reform split into two some spindle microtubules shorten D telophase reforms at maximum spindle microtubules distance from cell break down equator

1 marks

Answer: D

This question in 9700/12 Feb/March 2022

21 The photomicrograph shows cells at different stages of mitosis. P T Q S R A student wrote four statements about the photomicrograph. 1 Cell P shows anaphase. 2 Spindle formation is occurring in cell Q. 3 The amount of DNA in cell R is the same as in cell T. 4 The correct order for the stages is S  R  T  P  Q. Which statements are correct? A 1, 2 and 3 B 1, 2 and 4 C 1, 3 and 4 D 2, 3 and 4

1 marks

Answer: C

This question in 9700/11 May/June 2022

20 What occurs during prophase in animal cells? 1 fragmentation of the nuclear envelope 2 nucleolus disappears 3 stained chromosomes become visible 4 centrioles replicate A 1, 2, 3 and 4 B 1, 2 and 3 only C 2 and 3 only D 1 and 4 only

1 marks

Answer: B

This question in 9700/12 May/June 2022

19 Which statements about mitosis are correct? 1 At the end of telophase, two nuclei are formed. 2 Centrioles attach chromosomes to the spindle during metaphase. 3 Chromatids are pulled apart during anaphase. A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only

1 marks

Answer: C

This question in 9700/13 May/June 2022

21 The diagram shows stages of mitosis. 1 1 3 3 2 2 5 5 4 4 What is the correct sequence of the stages of mitosis numbered on the diagram? A 1  3  4  2  5 B 1  3  4  5  2 C 3  1  4  5  2 D 3  4  1  2  5

1 marks

Answer: C

This question in 9700/13 May/June 2022

19 Which row shows the correct number of each component of a single chromosome at the end of prophase of mitosis? polynucleotide centromeres chromatids telomeres strands A 1 0 2 2 B 1 2 4 4 C 2 0 4 2 D 2 2 2 4

1 marks

Answer: B

This question in 9700/11 Oct/Nov 2022

21 Stained onion cells undergoing mitosis were observed using a microscope. Which row is correct for mitosis in plant cells? prophase metaphase anaphase telophase A centrioles chromosomes pair two telomeres are two nuclear visible up at the equator visible on each membranes form chromatid B centromeres chromosomes align chromosomes centrioles present at the equator replicate to disappear form chromatids C each chromosome centromeres attach chromatids separate chromosomes is visible as two to spindle fibres and migrate decondense chromatids to opposite poles D spindle fibres formed centromeres attach chromatids are spindle fibres by centrioles to spindle fibres pulled apart form new nuclear by centrioles membranes

1 marks

Answer: C

This question in 9700/12 Oct/Nov 2022

18 Which row shows the correct number of each component in a single chromosome at the start of telophase of mitosis? polynucleotide centromeres telomeres strands A 1 2 2 B 1 4 4 C 2 4 2 D 2 2 4

1 marks

Answer: A

This question in 9700/13 Oct/Nov 2022

17 The cell cycle includes mitosis. What are features of this type of nuclear division? 1 forms cells of equal size to the parent cell 2 forms genetically identical nuclei 3 semi-conservative replication of DNA A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 only

1 marks

Answer: D

This question in 9700/11 May/June 2023

18 A student observed the cells in the growing region (meristem) of an onion root and obtained the data shown. number stage of cells interphase 886 prophase 73 metaphase 16 anaphase 14 telophase 11 Which percentage of cells contains chromosomes that appear as two chromatids? A 7.3% B 8.9% C 95.9% D 97.5%

1 marks

Answer: B

This question in 9700/11 May/June 2023

20 The diagram shows part of the organisation of a section of a DNA molecule and the associated histones, P and R, in prophase of mitosis. P Q R Which statement about the features labelled P, Q and R during prophase of mitosis is correct? A The coiled DNA molecule forms Q and wraps around histone R to form small clusters held in place by histone P. B The groups of histones, P, and its associated DNA, Q, move closer together as the chromosome condenses around R. C The histones P and R are made of protein around which the DNA molecule, Q, is wrapped so that the DNA molecule can fit inside the nucleus. D The linked groups of histones P and R and the associated DNA, Q, form strands that fold and twist together to form a chromatid.

1 marks

Answer: D

This question in 9700/12 May/June 2023

6 How many of the listed structures typically contain genetic material that has telomeres? • bacterial cell • chloroplast • mitochondrion • nucleus A 1 B 2 C 3 D 4

1 marks

Answer: A

This question in 9700/13 May/June 2023

4 Centrioles, cilia, microtubules and microvilli are structures found in eukaryotic cells. Which statement about these cellular structures is correct? A Centrioles, cilia and microvilli are composed of microtubules. B Centrioles play a role in mitosis and semi-conservative DNA replication. C Cilia and microvilli both increase the cell surface area for absorption. D Microtubules are made of protein and form the spindle in mitosis.

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2023

20 Which statement about the behaviour of chromosomes during telophase is correct? A Chromosomes attach to the spindle fibres at the equator. B Chromosomes start to uncoil inside the newly formed nucleus. C Chromosomes move towards the opposite poles of the cell. D Chromosomes condense into compact structures in the cytoplasm.

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2023

21 The transmission electron micrograph shows a cell in a stage of the mitotic cell cycle. Which statement explains why it is difficult to identify the stage of the mitotic cell cycle shown? A Chromosomes have supercoiled and are visible, but centrioles are not visible. B Anaphase may be continuing, or telophase may be starting. C It is unclear whether the electron micrograph shows two cells in metaphase. D Some people may consider interphase to have started.

1 marks

Answer: B

This question in 9700/13 Oct/Nov 2023

20 During sperm formation in mammals, part of the structure of each chromosome is replaced with proteins called protamines. This replacement allows the DNA to be packaged much more densely than would otherwise be possible. Which part of the chromosome is replaced by protamines? A centromeres B chromatids C histones D telomeres

1 marks

Answer: C

This question in 9700/12 Feb/March 2024

21 The diagram shows the mitotic cell cycle. During which phase do chromosomes condense and become visible? cytokinesis D C A B

1 marks

Answer: D

This question in 9700/12 Feb/March 2024

18 Eukaryotic organisms grow and increase in size as a result of cell division. The diagram shows some stages of mitosis with one stage missing, labelled X. X What happens in stage X? A Spindle fibres attach to the centromeres and the chromosomes line up along the equator. B The chromatin coils and condenses and the nuclear membrane disintegrates. C The chromosomes line up in pairs along the equator of the cell. D Microtubules shorten so that spindle fibres contract and the centromeres divide.

1 marks

Answer: D

This question in 9700/11 May/June 2024

19 The graphs show various distance measurements taken from the start of metaphase of mitosis. The graphs are to scale when compared to one another. X distance time Y distance time Which row correctly identifies the distance measurement for each graph? X Y A distance between distance of centromeres poles of spindle from poles of spindle B distance between distance between poles of spindle sister chromatids C distance of centromeres distance between from poles of spindle sister chromatids D distance of centromeres distance between from poles of spindle poles of spindle

1 marks

Answer: C

This question in 9700/11 May/June 2024

20 Which row is correct for the start of anaphase of mitosis? DNA is associated state of the form of DNA with histone cell surface proteins membrane A chromosomes always broken apart B chromosomes sometimes intact C separated sister chromatids always intact D separated sister chromatids sometimes broken apart

1 marks

Answer: C

This question in 9700/11 May/June 2024

20 The graph shows the mean length of the spindle fibres during mitosis. Which region of the graph shows when all the centromeres have detached from the spindle fibres? B C mean length of spindle fibres A D time

1 marks

Answer: D

This question in 9700/12 May/June 2024

18 A high-power photomicrograph shows a cell in a stage of mitosis. The chromosomes are visible and lined up along the cell equator but there is no nuclear envelope. Which stage of mitosis is shown by the photomicrograph? A prophase B metaphase C anaphase D telophase

1 marks

Answer: B

This question in 9700/13 May/June 2024

20 A scientist stains the chromosomes of a plant cell with a fluorescent dye to observe the telomeres. This cell has 38 chromosomes. How many telomeres will the scientist observe in one of the nuclei during telophase of mitosis? A 38 B 76 C 114 D 152

1 marks

Answer: B

This question in 9700/13 May/June 2024

20 The photomicrograph shows a stage of mitosis. What would be correct for the next stage in mitosis? two sister nuclear chromatids remain membrane attached A no not present B no re-forming C yes not present D yes breaking down

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2024

24 There are 64 chromosomes in the muscle cells of a particular mammal. How many DNA molecules are present in a cell during early prophase and telophase of mitosis? early telophase prophase A 64 32 B 64 64 C 128 128 D 128 64

1 marks

Answer: C

This question in 9700/11 Oct/Nov 2024

18 Chickens have 78 chromosomes in the nucleus of a body cell. How many DNA molecules are there in a chicken body cell at the start of prophase of mitosis? A 46 B 78 C 92 D 156

1 marks

Answer: D

This question in 9700/12 Oct/Nov 2024

19 The photomicrograph shows cells undergoing mitosis. X Which statement describes what will happen next in cell X? A Chromatin coils up tightly and the nuclear envelope breaks down. B Chromosomes line up along the equator of the cell and attach to the spindle. C Sister chromatids move towards opposite poles, pulled by the spindle fibres. D Spindle fibres break down and the cell prepares for cytokinesis.

1 marks

Answer: B

This question in 9700/12 Oct/Nov 2024

19 The photomicrograph shows cells in an onion root tip. X Y Z Which labelled cells are in anaphase, metaphase and prophase? anaphase metaphase prophase A X Y Z B Y Z X C Z X Y D Z Y X

1 marks

Answer: D

This question in 9700/13 Oct/Nov 2024

20 The photomicrograph shows plant cells in different stages of the mitotic cell cycle. Four of the cells are labelled with a number to identify them. 2 3 1 4 One of the numbered cells is within the main stage of mitosis in which the spindle begins to form. A second numbered cell is within the main stage of mitosis in which the spindle fibres shorten. Which row correctly identifies the two cells that are in these stages of mitosis? stage in which stage in which spindle begins spindle fibres to form shorten A 1 2 B 2 1 C 3 1 D 4 2

1 marks

Answer: D

This question in 9700/12 Feb/March 2025

21 Which percentage of the chromosomal DNA present in a cell during G1 is present in the same cell later in the same mitotic cell cycle during prophase and during telophase? prophase telophase A 50% 25% B 50% 50% C 100% 50% D 100% 100%

1 marks

Answer: D

This question in 9700/12 Feb/March 2025

21 The diagram shows the arrangement of chromosomes with attached spindle fibres during a stage of mitosis. Which row correctly identifies the stage of mitosis and describes what is happening? stage of mitosis description A anaphase chromosomes are being pulled towards the centromeres B metaphase sister chromatids are replicating prior to separation C metaphase chromosomes are being positioned along the equator of the cell D anaphase sister chromatids are being pulled towards the poles of the cell

1 marks

Answer: D

This question in 9700/12 May/June 2025

23 Human body cells in interphase have 46 chromosomes. What is correct about the number of telomeres present in prophase of a human body cell? A 46 as there is one telomere at the end of 46 chromosomes B 92 as there is one telomere at each end of 46 chromosomes C 92 as there is one telomere at the end of 92 chromatids D 184 as there is one telomere at each end of 92 chromatids

1 marks

Answer: D

This question in 9700/12 May/June 2025

21 A cell is in mitosis. Each of the chromosomes in the cell consists of two chromatids. The chromosomes are not lined up at the equator. Which stage of mitosis is described? A prophase B metaphase C anaphase D telophase

1 marks

Answer: A

This question in 9700/13 May/June 2025

22 The diagrams show two stages of the cell cycle in different organisms. The number of specific structures in each diagram is counted. Which row shows the correct combined total for the different structures? chromosomes centromeres telomeres A 5 3 8 B 5 5 16 C 8 3 16 D 8 5 8

1 marks

Answer: B

This question in 9700/13 May/June 2025

22 What is the role of telomeres? A allowing the chromatids to reach the poles during mitosis B holding sister chromatids together C making sure that the sister chromatids are of identical length D preventing loss of genes during DNA replication

1 marks

Answer: D

This question in 9700/14 May/June 2025

23 Which features of mitosis help to maintain the genetic composition of the cell? 1 the longitudinal division of the centromeres 2 the DNA of the parent cells replicates before mitosis begins 3 the pulling apart of the chromatids to opposite poles A 1, 2 and 3 B 1 and 3 only C 1 only D 2 and 3 only

1 marks

Answer: A

This question in 9700/14 May/June 2025

19 A human muscle cell contains 46 chromosomes. How many centromeres will be present in a cell during the stages of the mitotic cell cycle? early prophase metaphase anaphase A 46 46 92 B 46 92 92 C 46 46 46 D 92 46 46

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2025

21 The photomicrographs show stages of mitosis. 1 2 3 4 5 What is the correct order for the stages of mitosis? A 2  3  5  1  4 B 2  4  1  5  3 C 3  2  5  4  1 D 5  1  4  3  2

1 marks

Answer: A

This question in 9700/11 Oct/Nov 2025

23 The photomicrograph shows a stage of the cell cycle. Which stage is shown in the photomicrograph? A anaphase B interphase C metaphase D telophase

1 marks

Answer: C

This question in 9700/13 Oct/Nov 2025