B10.1· 11 questions · 11 marks · 13 min · 2017–2025· Multiple choice
Every Cambridge IGCSE Science - Combined Paper 2 question on diseases and immunity, laid out as 3 A4 pages with the mark scheme below. Nothing is left out. Free to read, no account.




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3 / 3Answers below. Sit the paper first if you are practising.
Pastlit
Science - Combined 0653 · Diseases and immunity — Paper 2
IGCSE · topical answer key — answer key (teacher use)
Question
Answer
Marks
| Question | Answer | Marks | From |
|---|---|---|---|
| 1 | D | 1 | 0653/22 Feb/March 2017 |
| 2 | D | 1 | 0653/22 May/June 2017 |
| 3 | D | 1 | 0653/23 May/June 2017 |
| 4 | D | 1 | 0653/22 Feb/March 2018 |
| 5 | C | 1 | 0653/22 May/June 2023 |
| 6 | D | 1 | 0653/23 May/June 2024 |
| 7 | C | 1 | 0653/21 May/June 2025 |
| 8 | B | 1 | 0653/22 May/June 2025 |
| 9 | A | 1 | 0653/22 May/June 2025 |
| 10 | A | 1 | 0653/22 May/June 2025 |
| 11 | D | 1 | 0653/22 Oct/Nov 2025 |
11 How does HIV affect the immune system? A It decreases the number of platelets. B It destroys red blood cells. C It increases the number of white blood cells. D It reduces antibody formation.
1 marks
Answer: D
11 Which type of blood cell is affected by the human immuno-deficiency virus (HIV) and what effect does the virus have on those cells? type of blood cell effect on the blood cell A red prevents them carrying oxygen B red stops them from making the blood clot C white stops them from performing phagocytosis D white reduces antibody production
1 marks
Answer: D
11 What effect does HIV have on the components of blood? A Blood does not clot as quickly. B Plasma can no longer carry hormones. C Red blood cells carry less oxygen. D White blood cells make fewer antibodies.
1 marks
Answer: D
8 What are possible causes of coronary heart disease? exercise smoking stress A Jv Jv x B Jv x Jv Cc x x x D x Jv Jv
1 marks
Answer: D
8 A sample of blood is taken from a person who often gets infections. The blood is also slow to clot. Which blood components are likely to be at a lower level than normal? 1 platelets 2 red blood cells 3 white blood cells A 1, 2 and 3 B 1 and 2 only C 1 and 3 only D 2 and 3 only
1 marks
Answer: C
12 Which type of blood cell is affected by the human immunodeficiency virus (HIV) and which effect does the virus have on those cells? type of blood cell effect on the blood cell A red prevents them carrying oxygen B red reduces antibody production C white prevents them carrying oxygen D white reduces antibody production
1 marks
Answer: D
12 Which row shows how active immunity is gained? from antibodies supplied in an injection by vaccination after an infection by a pathogen \ \ & & key /=yes X =no
1 marks
Answer: C
8 What is a function of hydrochloric acid in the stomach? A to help absorption of all food in the stomach B to kill microorganisms in the ingested food C to prevent chemical digestion D to prevent the stomach contents being too acidic
1 marks
Answer: B
10 Which row describes viruses? are have a pathogens protein coat contain genetic material v v x x v x v x Qe Ow® OS
1 marks
Answer: A
12 Which statement about the use of antibiotics is correct? A Overuse of antibiotics causes the development of bacteria such as MRSA. B Antibiotics are prescribed for infections caused by viruses and bacteria. C Antibiotics increase reproduction of non-resistant bacteria. D Antibiotics only kill resistant bacteria.
1 marks
Answer: A
11 The diagrams show features of plant cells and viruses that are different and features that are common to both. Which diagram is correct? A B plant cell virus plant cell virus genetic ribosomes genetic material cell wall cell wall ribosomes material protein protein coat coat C D plant cell virus plant cell virus genetic ribosomes material protein genetic protein ribosomes coat material coat cell wall cell wall
1 marks
Answer: D