Cambridge A Level Biology 9700 — 2005 Oct/Nov Paper 1 · Variant 1

UNIVERSITY OF CAMBRIDGE INTERNATIONAL EXAMINATIONS General Certificate of Education Advanced Subsidiary Level BIOLOGY 9700/01 Paper 1 Multiple Choice October/November 2005 1 hour Additional Materials: Multiple Choice Answer Sheet Soft clean eraser Soft pencil (type B or HB is recommended) READ THESE INSTRUCTIONS FIRST Write in soft pencil. Do not use staples, paper clips, highlighters, glue or correction fluid. Write your name, Centre number and candidate number on the answer sheet in the spaces provided unless this has been done for you. There are forty questions on this paper. Answer all questions. For each question there are four possible answers A, B, C and D. Choose the one you consider correct and record your choice in soft pencil on the separate answer sheet. Read the instructions on the answer sheet very carefully. Each correct answer will score one mark. A mark will not be deducted for a wrong answer. Any rough working should be done in this booklet. This document consists of 16 printed pages. IB05 11_9700_01/RP  UCLES 2005 [Turn over

2 © UCLES 2005 9700/01/O/N/05 1 The diagram shows the ultrastructure of a typical animal cell. Which structure synthesises and transports lipids and steroids? A B C D 2 Which structures are found in plant cells but not in animal cells? A centrioles B mitochondria C nucleoli D plasmodesmata 3 What is the correct order of size of organelles? largest smallest A mitochondrion nucleus lysosome ribosome B mitochondrion nucleus ribosome lysosome C nucleus mitochondrion lysosome ribosome D nucleus mitochondrion ribosome lysosome

3 © UCLES 2005 9700/01/O/N/05 [Turn over 4 A piece of mammalian tissue was homogenised and centrifuged. The biochemical activity of four subcellular fractions was investigated. Which diagram indicates the fraction with maximum synthesis of messenger RNA? activity nuclei mitochondria lysosomes ribosomes A activity nuclei mitochondria lysosomes ribosomes B activity nuclei mitochondria lysosomes ribosomes C activity nuclei mitochondria lysosomes ribosomes D 5 The action of which cell depends on large numbers of lysosomes? A ciliated epithelial cell B goblet cell C lymphocyte D phagocyte 6 An amino acid enters a cell and is used to synthesise an enzyme secreted by the cell. What is the sequence of cell components involved in this pathway? first last A endoplasmic reticulum Golgi apparatus ribosome exocytotic vesicle B endoplasmic reticulum ribosome Golgi apparatus cell surface membrane C ribosome Golgi apparatus endoplasmic reticulum cell surface membrane D ribosome endoplasmic reticulum Golgi apparatus exocytotic vesicle

4 © UCLES 2005 9700/01/O/N/05 7 Which molecule in the key is sucrose? contains pentose sugar contains hexose sugar is a reducing sugar A B C D yes no yes no yes no 8 Bonds are formed by condensation in cellulose, sucrose and haemoglobin. What are the names of these bonds? cellulose sucrose haemoglobin A glycosidic ester ester B glycosidic glycosidic peptide C peptide glycosidic ester D peptide ester peptide 9 What will break an ionic bond between amino acids? A condensation B hydrolysis C low temperature D pH change

5 © UCLES 2005 9700/01/O/N/05 [Turn over 10 Diagrams 1, 2 and 3 show the structural formulae of three polysaccharides. 1 3 2 O O O O O O O O O O O O O O O O O O O O O O O What are the names of these polysaccharides? 1 2 3 A amylose cellulose glycogen B amylose glycogen cellulose C cellulose glycogen amylose D glycogen amylose cellulose

6 © UCLES 2005 9700/01/O/N/05 11 Four sugar solutions were tested with a standard Benedict’s solution. The table shows the colour of the solutions after testing. solution colour 1 green 2 blue 3 brick red 4 yellow What is the best interpretation of the results? solution 1 solution 2 solution 3 solution 4 A 0.05 % reducing sugar 0.5 % non-reducing sugar 1.0 % reducing sugar 0.1% reducing sugar B 0.5 % non-reducing sugar 0.05 % reducing sugar 0.1 % reducing sugar 1.0% reducing sugar C 1.0 % reducing sugar 1.0 % non-reducing sugar 1.5 % reducing sugar 0.5 % reducing sugar D 1.0 % non-reducing sugar 0.5 % reducing sugar 0.5 % non-reducing sugar 0.1 % non-reducing sugar 12 The diagram shows part of a polymer. C CH3 CH3 C H2N OH C N C H H O O H Which molecule is used to break the bond indicated by the arrow? A amino acid B amylase C peptide D water

7 © UCLES 2005 9700/01/O/N/05 [Turn over 13 Which statement is true of all enzymes? A They are denatured at temperatures above 60 °C. B They are inactivated at low pH values. C They catalyse the breakdown of large molecules into smaller ones. D They reduce the amount of energy required to start a reaction. 14 A quantity of an enzyme was added to a quantity of its substrate. The graphs show the changes in concentration of the enzyme, the substrate, the enzyme-substrate complex and the product over time. Which graph shows the change in the concentration of the enzyme-substrate complex? time time time time concentration concentration concentration concentration A B C D

8 © UCLES 2005 9700/01/O/N/05 15 What are the features of facilitated diffusion? uses protein channels in membrane uses ATP molecules move down a concentration gradient A    B    C    D    16 The table shows three processes that contribute to transport across cell surface membranes. Which processes are the result of random movement of molecules? diffusion endocytosis osmosis A    key B     = random C     = non random D    17 Red blood cells were placed in a solution of sodium chloride with a water potential higher (less negative) than the cell contents. Haemoglobin was released from the cells. By what process was the haemoglobin released? A active transport B exocytosis C facilitated diffusion D lysis of cell

9 © UCLES 2005 9700/01/O/N/05 [Turn over 18 The following events take place in the mitotic cell cycle. 1 Chromosomes condense. Centrioles separate and move to opposite poles of the cell. 2 Chromosomes unwind. Cytokinesis occurs. 3 Nuclear envelope disappears. Centromeres arranged at equator of spindle. 4 Sister chromatids pulled towards centrioles. What is the sequence of these events? first last A 1 3 4 2 B 1 4 2 3 C 3 2 4 1 D 3 4 1 2 19 The diagram shows an animal cell which is undergoing mitotic division. Which stage of mitosis has been reached? A anaphase B metaphase C prophase D telophase 20 The diagram represents the life cycle of an animal. At which stage in the life cycle does mitosis occur? n n n n A B 2n 2n 2n C D

10 © UCLES 2005 9700/01/O/N/05 21 Which diagram shows the bond linking the individual units of a nucleic acid? C O A B C C N H C O C C O C O C C O P C D O C 22 Tuberculosis (TB) is treated with a combination of antibiotics including rifampicin and streptomycin. • rifampicin inhibits polymerisation of bacterial RNA • streptomycin binds to and inhibits bacterial ribosomes Which stages of protein synthesis are inhibited by rifampicin and streptomycin? rifampicin streptomycin A transcription transcription B transcription translation C translation transcription D translation translation

11 © UCLES 2005 9700/01/O/N/05 [Turn over 23 A polypeptide has the amino acid sequence glycine – arginine – lysine – serine. The table gives possible tRNA anticodons for each amino acid. amino acid tRNA anticodons arginine UCC GCG glycine CCA CCU lysine UUC UUU serine AGG UCG Which sequence of bases on DNA would code for the polypeptide? A CCACGCAAGAGC B CCTTCCTTCTCG C GGAAGGAAAAGC D GGTTGGTTGTGC 24 The table shows the percentages of nitrogenous bases in four samples of nucleic acids. Which base is adenine? bases sample A B C D uracil 1 19 31 30 19 nil 2 27 23 24 26 nil 3 25 25 nil 25 25 4 17 32 33 18 nil 25 The diagram shows some adjacent cells from the root of a plant. Which is the symplast pathway of water movement? A B C D

12 © UCLES 2005 9700/01/O/N/05 26 How is sucrose transported into companion cells and then into phloem sieve tubes? transport into companion cell transport into sieve tubes A by active transport against a concentration gradient through plasmodesmata B by diffusion against a concentration gradient through plasmodesmata C by active transport down a concentration gradient by diffusion D by diffusion down a concentration gradient by diffusion 27 In which combination of environmental conditions are the stomata of a plant most likely to close? atmospheric humidity soil water potential wind speed A high high high B high low low C low high low D low low high 28 Which feature enables the aorta to withstand high pressure at ventricular systole? A collagen fibres and elastin fibres B collagen fibres and semilunar valves C elastin fibres and large lumen D semilunar valves and smooth muscle

13 © UCLES 2005 9700/01/O/N/05 [Turn over 29 The diagram shows pressure changes in the left side of the heart during the cardiac cycle. 20 10 0 -1 0 0.2 0.4 0.6 0.8 pressure / kPa time / s left ventricle aorta left atrium key X What happens at X? A atrioventricular valves close B atrioventricular valves open C semilunar valves close D semilunar valves open 30 The graph shows the oxygen haemoglobin dissociation curves at pH 7.6 and at pH 7.2. Which point on the graph shows the percentage saturation of haemoglobin in the blood leaving an active muscle? partial pressure of oxygen % saturation of haemoglobin pH 7.6 pH 7.2 A B C D

14 © UCLES 2005 9700/01/O/N/05 31 A person with emphysema must consciously contract muscles in order to breathe out. What makes this muscle contraction necessary? A constriction of the bronchioles B excess mucus blocking the air passages C loss of elasticity in the alveolar walls D paralysis of cilia in the air passages 32 Which component of tobacco smoke makes the blood platelets sticky causing an increased risk of clot formation? A carbon monoxide B carcinogens C nicotine D tar 33 The table shows a person’s lung volumes during quiet breathing and at full inspiration and full expiration. lung volume / dm3 during quiet breathing 3–3.5 at full inspiration 5.2 at full expiration 1.5 What is this person’s vital capacity? A 1.7 dm3 B 2.0 dm3 C 3.7 dm3 D 5.2 dm3 34 Which disease is correctly linked to its causative agent and method of infection? disease causative agent method of infection A cholera bacterium ingestion B HIV / AIDS virus water-borne C malaria bacterium blood transfusion D tuberculosis (TB) virus inhalation

15 © UCLES 2005 9700/01/O/N/05 [Turn over 35 Many doctors now restrict prescriptions for some antibiotics. They keep the most effective antibiotics in reserve for the most serious outbreaks of treatable diseases. What is the main reason for this? A Antibiotics are not as effective as other medicines. B Antibiotics are only effective against diseases caused by bacteria. C Resistant strains of bacteria may develop. D Taking antibiotics may weaken the immune system. 36 In parts of London, there was an increase in the number of cases of tuberculosis (TB) in the 1990s. Which factor is most likely to have contributed to this? A increased air pollution B increased drug abuse C increased pathogen mutation rate D overcrowded accommodation 37 An enzyme hydrolyses the two heavy polypeptide chains of an antibody molecule. The hydrolysis occurs at the hinge region and breaks the antibody into three fragments. How many of these fragments are able to bind to antigen? A 0 B 1 C 2 D 3 38 Why has it proved difficult to develop a vaccine against malaria? A Mosquitoes have many stages in their life cycles. B The human immune system does not recognise the antigens of the parasite. C The parasites are only vulnerable to attack when outside the liver and red blood cells. D Vaccines are rapidly broken down by proteases in the stomach. 39 Which stage of energy transfer has the lowest efficiency? A sunlight → producer B producer → primary consumer C primary consumer → secondary consumer D secondary consumer → tertiary consumer

16 Every reasonable effort has been made to trace all copyright holders where the publishers (i.e. UCLES) are aware that third-party material has been reproduced. The publishers would be pleased to hear from anyone whose rights they have unwittingly infringed. University of Cambridge International Examinations is part of the University of Cambridge Local Examinations Syndicate (UCLES), which is itself a department of the University of Cambridge. © UCLES 2005 9700/01/O/N/05 40 Leguminous plants have root nodules containing bacteria. The diagram shows a transverse section through part of the root and root nodule of a leguminous plant. 1 2 3 4 What is indicated by the labels 1, 2, 3 and 4? 1 2 3 4 A phloem tissue sugar from host nitrogen amino acid to host B phloem tissue water from host ammonium ions nitrate to host C xylem tissue sugar from host nitrate ions water to host D xylem tissue water from host carbon dioxide sugar to host

UNIVERSITY OF CAMBRIDGE INTERNATIONAL EXAMINATIONS GCE Advanced Subsidiary Level and GCE Advanced Level MARK SCHEME for the November 2005 question paper 9700 BIOLOGY 9700/01 Paper 1 (Multiple Choice), maximum raw mark 40 Mark schemes must be read in conjunction with the question papers and the Report on the Examination. The minimum marks in these components needed for various grades were previously published with these mark schemes, but are now instead included in the Report on the Examination for this session. • CIE will not enter into discussion or correspondence in connection with these mark schemes. CIE is publishing the mark schemes for the November 2005 question papers for most IGCSE and GCE Advanced Level and Advanced Subsidiary Level syllabuses and some Ordinary Level syllabuses’.

Page 1 Mark Scheme Syllabus Paper A AND AS LEVEL – NOVEMBER 2005 9700 1 © University of Cambridge International Examinations 2005 Question Number Key Question Number Key 1 C 21 C 2 D 22 B 3 C 23 B 4 B 24 B 5 D 25 A 6 D 26 A 7 C 27 D 8 B 28 A 9 D 29 A 10 A 30 B 11 A 31 C 12 D 32 C 13 D 33 C 14 A 34 A 15 C 35 C 16 C 36 D 17 D 37 C 18 A 38 C 19 C 39 A 20 B 40 A